•   Programm 2009 als pdf-Dokument zum Download

 

ADVANCES IN CONGENITAL

DIAPHRAGMATIC HERNIA

OCTOBER 29TH - 30TH 2009

 Venue:

Zeughaus Mannheim C5

 Main Topics:

■          Etiology and Genetic Aspects

■          Pre- and Postnatal Management   

■          Standard of Care Clinical Trials

■          Long-term Outcome Learning from Animal Models

■          Future Directions

General Information

Venue:

Zeughaus Mannheim, C5

 

Congress Presidents:

Dick Tibboel, MD,PhD, Netherlands

Lucas Wessel, MD, Germany

 

Scientific and Organizing Committee:

Thomas Schaible, MD, Mannheim

Konrad Reinshagen, MD, Mannheim

Irwin Reiss, MD,PhD, Netherlands

 

Congress Secretaries:

Frederik Loersch, MD, Mannheim

Katrin Zahn MD, Mannheim

Phone:   0049 621 3832659

Fax:        0049 621 3832023.

No fees for congress!

 

Link to the venue:

www.rem-mannheim.de

service/besucherinfo/anfahrt.html

 

Accommodation:

Mercure or Holiday Inn Hotel Mannheim

close to the venue

 

Abstracts can be downloaded under

www.umm.de/1325.0.html

from next week on

 

For each Session, 2-3 additional oral

presentations are scheduled.

 

Accreditation: 12 credit points

(Deutsche Ärztekammer)

Dear Colleagues,

Our first interdisciplinary meeting in 2007, which focused on nearly all aspects in CDH in an interdisciplinary man­ner (including gynecologists, pediatricians, radiologists and pediatric surgeons) was very successful. It led to the formation of the Euro Consortium group, which now is performing a multicenter trial in ventilation. Despite ongoingclinical practice and scientific advances in the past two years, the management of CDH still remains a challen­ging task. Ethical and financial needs for more efficient, standardized therapies on the one side and the need to achieve progress in CDH-treatment and research on the other side urged us to put the questions: What are the advances so far? In what direction should we move? To discuss these questions we have again invited renowned specialists on all aspects of CDH to Mannheim. This year we performed the 500th ECMO run in Mannheim and more than half of the children were affected with a CDH. This meeting of experts from such a wide range of

specialties in neonatal medicine will raise awareness of each other’s challenges and might offer solutions by looking at aspects from another point of view. We look forward to welcoming you to Mannheim!

 

 

 

Dick Tibboel               Lucas Wessel

Program Day 1

Thursday, 29th October 2009

09:00 - 09:30

Welcome and Contribution to the 500th ECMO run in Mannheim

Chair: Prof. Dr. L. Wessel, Mannheim

Prof. Dr. Dr. h.c. med. Klaus van Ackern,

Dean of the Faculty Medical University Mannheim

Prof. em. Dr. med.  K. L. Waag, Department of Pediatric Surgery Mannheim

Prof. Dr. med. Walter Kachel, ECMO Pioneer, Germany

 

09:30 - 10:00 Special Lecture

Chair: Dick Tibboel, MD, PhD, Netherlands

■          The CDH Registry: A powerful tool in our understanding of CDH,

                Kevin Lally, MD, United States

 

10:00 - 10:30 Break

 

10:30 - 12:00 Etiology and Genetic Aspects in CDH

Chair: Annelies de Klein, MD, PhD, Netherlands, Dick Tibboel, MD, PhD, Netherlands

■          Overview of Genetic Factors in CDH, A. de Klein, MD, PhD, Netherlands

■          The use of array CGH for the detection of genomic imbalances in patients

                with CDH, P. Brady, Belgium

■          Diagnostic approach in case of syndromal patients with CDH,

                J. Tautz, MD, Germany

■          A der (5)t(5;12) mosaicism in a prenatal Congenital Diaphragmatic Hernia case -                         the usefulness of high-resolution array, D. Veenma MD, Netherlands

■          Embryology of the diaphragm, D.Kluth, MD, Germany

■          Agenesia of vena cava inferior in patients with right sided CDH,

                St. Hien, MD, Germany

■          Associated Anomalies in Congenital Diaphragmatic Hernia, K. Link, Germany

■          Perinatal risk factors and mortality in CDH infants, A. Conforti, MD, Italy

 

12:00 - 13:30 Lunch

 

13:30 - 15:30 Prenatal Management in CDH,

Chair: Jan Deprest, MD, PhD, Belgium, Marc Sütterlin, MD, Germany

■          Experience with isolated diaphragmatic hernia treated by fetal endoscopic

                tracheal occlusion (FETO) by the FETO consortium, J. Deprest MD, PhD, Belgium

■          Fetal hemodynamics and reactions to oxygen in CDH, T. Kohl, MD, Germany

■          MRI – Diagnostic in CDH, W. Neff, MD, PhD, Germany

■          Repetitive MRI measurements of lung volume in fetuses with CDH to investigate

                the serial time course of pulmonary hypoplasia during gestation,

                A.K. Kilian, MD, Germany

■          Prediction of chronic lung disease based on fetal MR lung volumetry in

                survivors with congenital diaphragmatic hernia, A. Debus, Germany

■          Correlation between the observed to expected ratio of the sonographic LHR

                and the MRI total fetal lung volume in isolated congenital diaphragmatic hernia,

                I. Sandaite, MD, Belgium

■          Volume assessment by 3D-ultrasound in congenital diaphragmatic hernia,

                S. Kehl, Germany

■          Maternal hyperoxygenation test in fetuses with congenital diaphragmatic hernia

                as a predictor of neonatal outcome, E. Done MD, Belgium

■          Effects of maternal glucocorticoid administration on gene expression levels after

                fetal tracheal occlusion in the nitrofen rat model for CDH, S. Mayer, Belgium/Germany

 

15:30 - 16:00 Break

 

16:00 - 17:30 Ventilation and Pharmacological Strategies

Chair: Irwin Reiss, MD, PhD, Netherlands Hans-Jürgen Rapp, MD, Germany

■          Modern Treatment of Pulmonary Hypertension, D. Schranz, MD, Germany

■          ECMO as a Treatment Option in CDH, A. van Heijst, MD, PhD, Netherlands

■          European Consensus Guidelines in CDH, T. Schaible, MD, Germany

■          Minimally invasive CDH-repair – Focus on perioperative management

                as a new aspect?, C. Gernoth, MD, Germany

■          Measurement of functional residual capacitiy and lung compliance prior and

                after surgical repair of congenital diaphragmatic hernia might help improve

                outcome: observations in 10 patients, K. Stadler, MD, Germany

■          Risk factors for chronic lung disease and early death in newborns with

                congenital diaphragmatic hernia in Europe, L. van den Hout, MD, Netherlands

 

17:30 - 18:00 Break

 

18:00 - 19:30 CDH-Euro-Consortium

 

Meeting concerning the VICI Trial

Chair: Irwin Reiss, MD, PhD, Netherlands

■          FAQ and update of Study Progress

 

20:00 - 00:00

Congress Party and Dinner at Restaurant Cfive

Admission fee 30 € (dinner and drinks are included)

tickets are available at the registration desk

Program Day 1

Thursday, 29th October 2009

Program Day 2

Friday, 30th October 2009

08.30 - 10.30 Surgical Aspects in CDH

Chair: Lucas Wessel, MD, Mannheim, Germany Pietro Bagolan, MD,PhD, Rome, Italy

■          Progress in Surgical Repair of CDH, P. Bagolan, MD,PhD, Italy

■          Management of GER in CDH, K. Reinshagen, MD, Germany

■          Thoracoscopic CDH-repair: pro’s and Contra’s- a single centre experience,

                K. van de Ven,  Netherlands

■          Recurrence after CDH-repair – the impact of surgical techniques,

                L. Wessel, MD, Germany

■          Study of gastroesophageal and intestinal innervation and motility in rats and

                babies with congenital diaphragmatic hernia, F. Perderiva, MD, Spain

■          TOTAL Trials for moderate and severe pulmonary hypoplasia as a consequence of

                isolated congenital diaphragmatic hernia – 9 months after kick off, J. Deprest MD,

                PhD, Belgium

■          Results of Tracheal occlusion versus non- Tracheal occlusion, a single centre

                experience, F. Loersch, MD, Germany

■          Tracheal occlusion early in gestation leads to greater lung growth and improved

                remodeling of pulmonary arteries, V. Beck, MD, Belgium

■          Tracheal occlusion in experimental diaphragmatic hernia: correlation between lung

                morphometry and haemodynamics, J. Prat, MD, Spain

 

10:30 - 11:00 Break

 

11:00 - 12:50 Long-term Outcome

Chair: Hanneke Meijers-Ijsselstijn, MD, PhD, Netherlands, Ludwig Gortner MD, Germany

■          Pulmonary Outcome and Lung function Measurement,

                H. Meijers-Ijsselstijn, MD, PhD, Netherlands

■          Neurological Outcome and Follow up Program, S. Gischler, MD, PhD, Netherlands

■          Health related quality of life in children with congenital diaphragmatic hernia at the

                ECMO-Centre Mannheim, F. Orth, MD, Germany

■          Long-term results after Extracorporeal Membrane Oxygenation in 64 neonates with

                congenital diaphragmatic hernia, K. Zahn, MD, Germany

■          Right versus left-sided congenital diaphragmatic hernia – postnatal outcome at a

                specialized tertiary care centre, K. Büsing, MD, Germany

■          Morbidity in infants affected by CDH, L. Valfre, MD, Italy

■          Sensorineural hearing loss and severe neonatal respiratory failure, P. Midrio, MD, Italy

■          Mortality in congenital diaphragmatic hernia: euphoria, depression, and the

                impact of “patient’s selection”, F. Morini, MD, Italy

■          Survival in CDH babies < 24 hrs of age in Royal Children’s Hospital, Melbourne,

                P. Loughnan, MD, Australia

 

12:50 - 14:00 Lunch

 

14:00 - 16:00 Translational research in CDH

Chair: Kevin Lally, MD, United States, Dick Tibboel MD, PhD, Netherlands

■          Lung Developmental Aspects, R. Rottier, PhD, Netherlands

■          Vascular Remodeling in Pulmonary Hypertension, R. Schermuly, PhD, Germany

■          The Vitamine A pathway and the clinical relevance in CDH,

                N. Beurskens, MD, Netherlands

■          Effect of retinoic acid and amniotic fluid stem cells on nitrofen-exposed

                rat heart explants, F. Pederiva, MD, Spain

■          Effect of antioxidant vitamins, retinoic acid and amniotic fluid stem cells on growth,

                innervation and motility in nitrofen-exposed hypoplastic rat lungs, F. Pederiva, MD, Spain

■          Congenital diaphragmatic hernia (CDH), Fog2, and myogenesis proteins,

                PG. Gamba, MD, Italy

■          Differential cytokine and chemokine expression profile in human cord blood

                mononuclear cells determined by the Toll-like receptor adapter molecule MyD88,

                J. Hoppstädter, MD, Germany

■          Cytokine profiles in CDH patients as a prognostic tool for the need of ECMO,

                M. Veit, Germany

■          Future Directions and Conclusion Remarks, D. Tibboel, MD, PhD, Netherlands

Program Day 2

Friday, 30th October 2009

We kindly invite the participants of the symposium

to visite the exhibition: