MDS-Verbundprojekt
bei der Deutschen Krebshilfe beantragt

Sprecher:
Prof. Dr. Wolf-Karsten Hofmann

Co-Sprecher:
Prof. Dr. Ulrich Germing

Projektleiter:
Prof. Dr. Ulrich Germing, Düsseldorf / Prof. Dr. Detlef Haase, Göttingen / Prof. Dr. Hans H. Kreipe, Hannover / PD Dr. Aristoteles Giagounidis, Duisburg
Analyses and coalescing of Clinical, Diagnostic and Translational Data of patients with Myelodysplastic Syndromes within the MDS-Registry

Prof. Dr. Norbert Gattermann, Düsseldorf / PD Dr. Michael Heuser / Dr. Felicitas Thol, Hannover
Centralized biobanking and molecular characterization of MDS specimens

PD Dr. Andrea Kündgen / Dr. Stefan Lehr, Düsseldorf
Comprehensive serum protein profiling for biomarker discovery in patients with myelodysplastic syndromes

Prof. Dr. H. Kreipe / Dr. Kais Hussein, Hannover
Cellular signals and apoptosis in early bone marrow fibrosis of MDS

Prof. Dr. Brigitte Schlegelberger / PD Dr. Gudrun Göhring, Hannover
Role of TP53 for induction of chromosomal instability in MDS with complex karyotypes

Prof. Dr. Michael Rehli / Dr. Daniel Heudobler, Regensburg
Integrated analysis of epigenetic and genetic changes during MDS progression

Prof. Dr. Detlef Haase, Göttingen
Sequential comprehensive genetic analysis of circulating CD34+ cells in MDS

PD Dr. Uwe Platzbecker / Prof. Dr. Lorenz C. Hofbauer / Dr. Martina Rauner, Dresden
Modulation of the bone microenvironment in myelodysplastic syndromes by iron overload, erythropoietin effects, and allogeneic hematopoietic stem cell transplantation

Prof. Dr. Wolf-Karsten Hofmann / Dr. Daniel Nowak, Mannheim
Characterization of molecular targets associated with aging of hematopoietic stem cells and hematopoietic niche cells in MDS patients versus healthy old and healthy young individuals

Prof. Dr. Arnold Ganser / PD Dr. Michael Heuser / Dr. Felicitas Thol, Hannover
Development of a functional human MDS model

Prof. Dr. Charlotte Niemeyer / PD Dr. Christian Flotho, Freiburg
Epigenetic modifications in childhood bone marrow failure syndromes and pediatric myelodysplastic syndromes

Prof. Dr. Tim Brümmendorf, Aachen / Prof. Dr. Norbert Gattermann, Düsseldorf
The role of telomere biology and iron overload for disease progression of MDS