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Key publications

  1. “Impact of pulmonary hypertension on outcomes after TEER in patients suffering from mitral regurgitation” Philippa Jaeger, Ioannis Toskas, Jessica-Kristin Henes, Serhii Shcherbyna, Frederic Schwarz, Miriam Euper, Peter Seizer, Harald Langer, Andreas E. May, Tobias Geisler, Meinrad Gawaz, Jürgen Schreieck & Dominik Rath. Clinical Research in Cardiology (2025) 114:203–214. DOI: 10.1007/s00392-024-02442-1 Epub: 02.04.2024
  2. “An unexpected cellular fountain of youth: platelets provide factors rejuvenating brain functions.” Langer, H.F. Sig Transduct Target Ther 8, 461 (2023). DOI: 10.1038/s41392-023-01716-w. Epub 29.12.2023.
  3. “Platelets Regulate Ischemia-Induced Revascularization and Angiogenesis by Secretion of Growth Factor Modulating Factors.” Nording, H M., Lasse Baron, Manuela Sauter, Antje Lübken, Elias Rawish, Rebecca D Szepanowski, Jacob von Esebeck, Ying Sun, Hossein Emami, Moritz Meusel, Roza Saraei, Nancy Schanze, Sivahari Prasad Gorantla, Nikolas von Bubnoff, Tobias Geisler, Philipp von Hundelshausen, Konstantinos Stellos, Jens Marquardt, Christian Sadik, Jörg Koehl, Daniel Duerschmied, Christoph Kleinschnitz, and Harald F. Langer. 2023. Blood Advances, May. Elsevier. DOI: 10.1182/bloodadvances.2021006891. Epub 14.11.2023. PMID:37257194. PMCID: PMC10598500
  4. VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway. Lee C, Chen R, Sun G, Liu X, Lin X, He C, Xing L, Liu L, Jensen LD, Kumar A, Langer HF, Ren X, Zhang J, Huang L, Yin X, Kim J, Zhu J, Huang G, Li J, Lu W, Chen W, Liu J, Hu J, Sun Q, Lu W, Fang L, Wang S, Kuang H, Zhang Y, Tian G, Mi J, Kang BA, Narazaki M, Prodeus A, Schoonjans L, Ornitz DM, Gariepy J, Eelen G, Dewerchin M, Yang Y, Ou JS, Mora A, Yao J, Zhao C, Liu Y, Carmeliet P, Cao Y, Li X. Signal Transduct Target Ther. 2023 Aug 18;8(1):305. doi: 10.1038/s41392-023-01539-9.
  5. “Modification of the GRACE Risk Score for Risk Prediction in Patients With Acute Coronary Syndromes.” Georgios Georgiopoulos, , Simon Kraler, , Matthias Mueller-Hennessen,  Dimitrios Delialis,  Georgios Mavraganis,  Kateryna Sopova,  Florian A. Wenzl,  Lorenz Räber,  Moritz Biener,  Barbara E. Stähli,  Eleni Maneta,  Luke Spray,  Juan F. Iglesias,  Jose Coelho-Lima, Simon Tual-Chalot, Olivier Muller, François Mach,  Norbert Frey,  Daniel Duerschmied,  Harald F. Langer,  Hugo Katus,  Marco Roffi,  Giovanni G. Camici, Christian Mueller,  Evangelos Giannitsis,  Ioakim Spyridopoulos,  Thomas F. Lüscher,  Konstantinos Stellos,  Kimon Stamatelopoulos. JAMA Cardiol. 2023;8(10):946–956. DOI:10.1001/jamacardio.2023.2741. Epub: 06.07.2023.
  6. “Improved mid-term stability of MR reduction with an increased number of clips after percutaneous mitral valve repair in functional MR.” Reinhard Sauter, Chaolan Lin, Harry Magunia, Juergen Schreieck, Daniel Dürschmied, Meinrad Gawaz, Johannes Patzelt, Harald F. Langer. IJC Heart & Vasculature, Volume 45. 2023. ISSN: 2352-9067. DOI: 10.1016/j.ijcha.2023.101190. Epub: 10.03.2023.
  7. “ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury.” Anne-Katrin Rohlfing, Kyra Kolb, Manuel Sigle, Melanie Ziegler, Alexander Bild, Patrick Münzer, Jessica Sudmann, Valerie Dicenta, Tobias Harm, Mailin-Christin Manke, Sascha Geue, Marcel Kremser, Madhumita Chatterjee, Chunguang Liang, Hendrik von Eysmondt, Thomas Dandekar, David Heinzmann, Manina Günter, Saskia von Ungern-Sternberg, Manuela Büttcher, Tatsiana Castor, Stine Mencl, Friederike Langhauser, Katharina Sies, Diyaa Ashour, Mustafa Caglar Beker, Michael Lämmerhofer, Stella E. Autenrieth, Tilman E. Schäffer, Stefan Laufer, Paulina Szklanna, Patricia Maguire, Matthias Heikenwalder, Karin Anne Lydia Müller, Dirk M. Hermann, Ertugrul Kilic, Ralf Stumm, Gustavo Ramos, Christoph Kleinschnitz, Oliver Borst, Harald F. Langer, Dominik Rath & Meinrad Gawaz. Nat Commun 13, 1823 (2022). DOI: 10.1038/s41467-022-29341-1. Epub 05.04.2022.
  8. “Activated Platelets Upregulate β2 Integrin Mac-1 (CD11b/CD18) on Dendritic Cells, Which Mediates Heterotypic Cell–Cell Interaction.” Henry Nording, Manuela Sauter, Chaolan Lin, Rebecca Steubing, Sven Geisler, Ying Sun, Joel Niethammer, Fréderic Emschermann, Yunmei Wang, Barbara Zieger, Bernhard Nieswandt, Christoph Kleinschnitz, Daniel I. Simon, Harald F. Langer. J Immunol 1 April 2022. 208 (7): 1729–1741. DOI: 10.4049/jimmunol.2100557. Epub 01.04.2022.
  9. “The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets.” Nording H, Baron L, Haberthür D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Köhl J, Gawaz M, Langer HF. Nat Commun. 2021 Jun 7;12(1):3352. DOI: 10.1038/s41467-021-23499-w. PMID: 34099640; PMCID: PMC8185003.
  10. “Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb.” Köhler D, Granja T, Volz J, Koeppen M, Langer HF, Hansmann G, Legchenko E, Geisler T, Bakchoul T, Eggstein C, Häberle HA, Nieswandt B, Rosenberger P. Nat Commun. 2020 Mar 11;11(1):1315. DOI: 10.1038/s41467-020-14958-x. PMID: 32161256; PMCID: PMC7066172.
  11. “Elevated Mitral Valve Pressure Gradient Is Predictive of Long-Term Outcome After Percutaneous Edge-to-Edge Mitral Valve Repair in Patients With Degenerative Mitral Regurgitation ( MR ), But Not in Functional MR.” Patzelt J, Zhang W, Sauter R, Mezger M, Nording H, Ulrich M, Becker A, Patzelt T, Rudolph V, Eitel I, Saad M, Bamberg F, Schlensak C, Gawaz M, Boekstegers P, Schreieck J, Seizer P, Langer HF. J Am Heart Assoc. 2019 Jul 2;8(13):e011366. DOI: 10.1161/JAHA.118.011366. Epub 2019 Jun 28. PMID: 31248323; PMCID: PMC6662353.
  12. Improved mitral valve coaptation and reduced mitral valve annular size after percutaneous mitral valve repair (PMVR) using the MitraClip system. Patzelt J, Zhang Y, Magunia H, Ulrich M, Jorbenadze R, Droppa M, Zhang W, Lausberg H, Walker T, Rosenberger P, Seizer P, Gawaz M, Langer HF. Eur Heart J Cardiovasc Imaging. 2018 Jul 1;19(7):785-791. DOI: 10.1093/ehjci/jex173.
  13. “Percutaneous Edge-to-Edge Mitral Valve Repair Using the New MitraClip XTR System.” Jorbenadze R, Schreieck J, Barthel C, Seizer P, Schlensak C, Gawaz M, Patzelt J, Langer HF. JACC Cardiovasc Interv. 2018 Jun 25;11(12):e93-e95. DOI: 10.1016/j.jcin.2018.04.005. Epub 2018 May 30. PMID: 29860072.
  14. “Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.” Sauter RJ, Sauter M, Reis ES, Emschermann FN, Nording H, Ebenhöch S, Kraft P, Münzer P, Mauler M, Rheinlaender J, Madlung J, Edlich F, Schäffer TE, Meuth SG, Duerschmied D, Geisler T, Borst O, Gawaz M, Kleinschnitz C, Lambris JD, Langer HF. Circulation. 2018 Oct 16;138(16):1720-1735. DOI: 10.1161/CIRCULATIONAHA.118.034600.
  15. A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis. Wen L, Feil S, Wolters M, Thunemann M, Regler F, Schmidt K, Friebe A, Olbrich M, Langer H, Gawaz M, de Wit C, Feil R. Nat Commun. 2018 Oct 16;9(1):4301. doi: 10.1038/s41467-018-06638.
  16. “Comparison of Deep Sedation With General Anesthesia in Patients Undergoing Percutaneous Mitral Valve Repair.” Patzelt J, Ulrich M, Magunia H, Sauter R, Droppa M, Jorbenadze R, Becker AS, Walker T, von Bardeleben RS, Grasshoff C, Rosenberger P, Gawaz M, Seizer P, Langer HF. J Am Heart Assoc. 2017 Dec 2;6(12):e007485. DOI: 10.1161/JAHA.117.007485. PMID: 29197832; PMCID: PMC5779052.
  17. Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography. Thunemann M, Schörg BF, Feil S, Lin Y, Voelkl J, Golla M, Vachaviolos A, Kohlhofer U, Quintanilla-Martinez L, Olbrich M, Ehrlichmann W, Reischl G, Griessinger CM, Langer HF, Gawaz M, Lang F, Schäfers M, Kneilling M, Pichler BJ, Feil R. Nat Commun. 2017 Sep 5;8(1):444. DOI: 10.1038/s41467-017-00482-y.
  18. “Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.” Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG. Nat Commun. 2016 May 18;7:11626. DOI: 10.1038/ncomms11626. PMID: 27188843; PMCID: PMC4873982.
  19. “Percutaneous Mitral Valve Edge-to-Edge Repair With Simultaneous Biatrial Intracardiac Echocardiography: First-in-Human Experience.” Patzelt J, Seizer P, Zhang YY, Walker T, Schreieck J, Gawaz M, Langer HF. Circulation. 2016 Apr 12;133(15):1517-9. DOI: 10.1161/CIRCULATIONAHA.115.020923. PMID: 27067088.
  20. “Effects of Mechanical Ventilation on Heart Geometry and Mitral Valve Leaflet Coaptation During Percutaneous Edge-to-Edge Mitral Valve Repair.” Patzelt J, Zhang Y, Seizer P, Magunia H, Henning A, Riemlova V, Patzelt TA, Hansen M, Haap M, Riessen R, Lausberg H, Walker T, Reutershan J, Schlensak C, Grasshoff C, Simon DI, Rosenberger P, Schreieck J, Gawaz M, Langer HF. JACC Cardiovasc Interv. 2016 Jan 25;9(2):151-9. DOI: 10.1016/j.jcin.2015.09.038. Epub 2015 Dec 23. PMID: 26723764.
  21. “Platelets induce apoptosis via membrane-bound FasL.” Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O’Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF. Blood. 2015 Sep 17;126(12):1483-93. DOI: 10.1182/blood-2013-12-544445. Epub 2015 Jul 31. Erratum in: Blood. 2016 Jan 14;127(2):270.
  22. “Percutaneous edge-to-edge mitral valve repair escorted by left atrial intracardiac echocardiography (ICE).” Henning A, Mueller II, Mueller K, Zuern C, Walker T, Gawaz M, Schreieck J, Langer HF. Circulation. 2014 Nov 11;130(20):e173-4. DOI: 10.1161/CIRCULATIONAHA.114.012504.
  23. “Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.” Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, DeAngelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD, Chavakis T. Blood. 2010 Nov 25;116(22):4395-403. DOI: 10.1182/blood-2010-01-261503. Epub 2010 Jul 12. PMID: 20625009; PMCID: PMC2996109.
  24. Histone H2AX is integral to hypoxia-driven neovascularization. Economopoulou M*, Langer HF*, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T. Nat Med. 2009 May;15(5):553-8. DOI: 10.1038/nm.1947. Epub 2009 Apr 19.
  25. “Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.” Choi EY, Chavakis E, Czabanka MA, Langer HF, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird WC, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T. Science. 2008 Nov 14;322(5904):1101-4. DOI: 10.1126/science.1165218.
  26. “Radionuclide imaging: a molecular key to the atherosclerotic plaque.” Langer HF, Haubner R, Pichler BJ, Gawaz M. J Am Coll Cardiol. 2008 Jul 1;52(1):1-12. DOI: 10.1016/j.jacc.2008.03.036.
  27. “Platelets in inflammation and atherogenesis.” Gawaz M, Langer H, May AE. J Clin Invest. 2005 Dec;115(12):3378-84. DOI: 10.1172/JCI27196.

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