Endothelial cAMP–Chemotaxis Signaling in Cardiac Function and Disease (Project Lead: Yohanes Wibowo)

During his Ph.D. studies, he discovered a novel role for endothelial cAMP signaling in tumor growth, angiogenesis, and metastasis using endothelial-specific knockout mice. Surprisingly, these cAMP-mediated effects affected not only cancer progression, but also immune regulation and cardiac function. This was demonstrated by the significant involvement of a chemotaxis factor and the drastic change in the phenotype and function of lymphoid organs. Building on his previous experience, he will investigate the impact of the chemotaxis factor on cardiac function and disease progression.