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Understanding the molecular mechanisms of cell death has been at the center of medical research for decades. In the past, apoptosis was at the center of this effort. However, emerging evidence has demonstrated that necrosis—a process once considered passive and unregulated—is, in fact, a well-regulated mechanism. Regulated necrosis is characterized by the rupture of the plasma membrane and the release of intracellular content, so-called damage associated molecular patterns (DAMPs). This process is now recognized as a critical step in the pathophysiology of various diseases, including acute kidney injury and the progression to chronic kidney disease (CKD).
Our lab investigates the distinct forms of regulated necrosis, including necroptosis and ferroptosis, and their roles in renal injury, nephron loss, and organ transplantation. Understanding these pathways not only clarifies disease mechanisms but might also reveal novel options for therapeutic intervention aimed at preventing or mitigating kidney damage.