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Course of colonization by multidrug-resistant organisms after allogeneic hematopoietic cell transplantation.
Heidenreich D, Kreil S, Jawhar M, Müller N, Nolte F, Becker KP, Miethke T, Hofmann WK, Klein SA.
Ann Hematol. 2018 Dec;97(12):2501-2508. doi: 10.1007/s00277-018-3475-6.

Direct MS-Based Bacterial Identification of Blood Cultures. Comparison of an In-House TritonX-Protocol with Bruker-Sepsityper?
Kittel M, Greulich A, Findeisen P, Haselmann V, Burrer A, Willem C, Miethke T, Ahmad-Nejad P, Neumaier M.
Clin Lab. 2018 Oct 31;64(11). doi: 10.7754/Clin.Lab.2018.180522.

Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients.
Postina P, Skladny J, Boch T, Cornely OA, Hamprecht A, Rath PM, Steinmann J, Bader O, Miethke T, Dietz A, Merker N, Hofmann WK, Buchheidt D, Spiess B.
Front Microbiol. 2018 Mar 27;9:555. doi: 10.3389/fmicb.2018.00555. eCollection 2018.


The inventory as a core element in the further development of the science curriculum in the Mannheim Reformed Curriculum of Medicine.
Eckel J, Schüttpelz-Brauns K, Miethke T, Rolletschek A, Fritz HM. GMS J Med Educ. 2017 May 15;34(2):Doc22. doi: 10.3205/zma001099. eCollection 2017.

Vaccination with the polymorphic membrane protein A reduces Chlamydia muridarum induced genital tract pathology. Müller T, Becker E, Stallmann S, Waldhuber A, Römmler-Dreher F, Albrecht S, Mohr F, Hegemann JH, Miethke T. Vaccine. 2017; 35:2801-2810.

Phosphotransferase systems in Enterococcus faecalis OG1RF enhance anti-stress capacity in vitro and in vivo.   Peng Z, Ehrmann MA, Waldhuber A, Niemeyer C, Miethke T, Frick JS, Xiong T, Vogel RF. Res Microbiol. 2017; doi: 10.1016/j.resmic.2017.03.003.

Immunity to uropathogens: the emerging roles of inflammasomes.Hamilton C, Tan L, Miethke T, Anand PK. Nat Rev Urol. 2017; 14:284-295.

Multidrug-resistant organisms in allogeneic hematopoietic cell transplantation. Heidenreich D, Kreil S, Nolte F, Hofmann WK, Miethke T, Klein SA. Eur J Haematol. 2017; 98:485-492


Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets.
Ambite I, Puthia M, Nagy K, Cafaro C, Nadeem A, Butler DS, Rydström G, Filenko NA, Wullt B, Miethke T, Svanborg C. PLoS Pathog. 2016; 12:e1005848.

Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation.
Waldhuber A, Puthia M, Wieser A, Cirl C, Dürr S, Neumann-Pfeifer S, Albrecht S, Römmler F, Müller T, Zheng Y, Schubert S, Groß O, Svanborg C, Miethke T.
J Clin Invest. 2016 Jul 1;126(7):2425-36. doi: 10.1172/JCI81916. Epub 2016 May 23.

A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.
Waldhuber A, Snyder GA, Römmler F, Cirl C, Müller T, Xiao TS, Svanborg C, Miethke T.

Pathogens. 2016 Feb 29;5(1). pii: E25. doi: 10.3390/pathogens5010025.

Direct comparison of galactomannan performance in concurrent serum and bronchoalveolar lavage samples in immunocompromised patients at risk for invasive pulmonary aspergillosis.
Boch T, Buchheidt D, Spiess B, Miethke T, Hofmann WK, Reinwald M.
Mycoses. 2016, 59:80-5.


Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells.
Römmler F, Hammel M, Waldhuber A, Müller T, Jurk M, Uhlmann E, Wagner H, Vollmer J, Miethke T.
PLoS One. 2015, 10:e0116703.

Rapid detection of cefotaxime-resistant Escherichia coli by LC-MS.Burrer A, Findeisen P, Jäger E, Ghebremedhin B, Grundt A, Ahmad-Nejad P, Miethke T, Neumaier M. Int J Med Microbiol. 2015, 305:860-4.


Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.
Snyder GA, Deredge D, Waldhuber A, Fresquez T, Wilkins DZ, Smith PT, Durr S, Cirl C, Jiang J, Jennings W, Luchetti T, Snyder N, Sundberg EJ, Wintrode P, Miethke T, Xiao TS.
J Biol Chem. 2014, 289:669-79. TM and TX are corresponding authors

Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB.
Través PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis EA, Martín-Sanz P, Palladino MA, Boscá L.
Chem Biol. 2014, 21:955-66.

Incidence of Cyp51 A key mutations in Aspergillus fumigatus-a study on primary clinical samples of immunocompromised patients in the period of 1995-2013.
Spiess B, Postina P, Reinwald M, Cornely OA, Hamprecht A, Hoenigl M, Lass-Flörl C, Rath PM, Steinmann J, Miethke T, Lauten M, Will S, Merker N, Hofmann WK, Buchheidt D.
PLoS One. 2014, 9:e103113.

Granzyme A produces bioactive IL-1β through a nonapoptotic inflammasome-independent pathwayHildebrand D, Bode KA, Rieß D, Cerny D, Waldhuber A, Römmler F, Strack J, Korten S, Orth JH, Miethke T, Heeg K, Kubatzky KF. Cell Rep. 2014, 9:910-7.


Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.
Snyder G.A., C. Cirl, J. Jiang, K. Chen, A. Waldhuber, P. Smith, F. Römmler, N. Snyder, T. Fresquez, S. Dürr, N. Tjandra, T. Miethke and T.S. Xiao.
ProcNatlAcadSci U S A. 110:6985-90. 2013. TM and TX are corresponding authors

Acute osteomyelitis of the humerus mimicking malignancy: Streptococcus pneumoniae as exceptional pathogen in an immunocompetent adult.
Prodinger, P. M., H. Pilge, I. J. Banke, D. Bürklein, R. Gradinger, T. Miethke, and B.M. Holzapfel.
BMC Infect Dis. 13:266, 2013.

Guanine-modification of inhibitory oligonucleotides potentiates their suppressive function.
Römmler, F., J. Jurk, E. Uhlmann, M. Hammel, A. Waldhuber, L. Pfeiffer, H. Wagner, J. Vollmer and T. Miethke.
J Immunol. 2013, 191:3240-53.


Rapid detection of ampicillin resistance in Escherichia coli by quantitative mass spectrometry.
Grundt, A., P. Findeisen, T. Miethke, E. Jäger, P. Ahmad-Nejad and M. Neumaier.
J. Clin. Microbiol. 50:1727-9, 2012

Candidiasis caused by Candida kefyr in a neonate: case report.
Weichert S, Reinshagen K, Zahn K, Geginat G, Dietz A, Kilian AK, Schroten H, Tenenbaum T.
BMC Infect Dis. 2012 Mar 18;12:61. doi: 10.1186/1471-2334-12-61.

Pseudomonas aeruginosa outbreak in a pediatric oncology care unit caused by an errant water jet into contaminated siphons.
Schneider H, Geginat G, Hogardt M, Kramer A, Dürken M, Schroten H, Tenenbaum T.
Pediatr Infect Dis J. 2012 Jun; 31(6): 648 - 50. doi: 10.1097 / INF. 0b013e31824d1a11

Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: identification by gas chromatography-tandem mass spectrometry and quantification by enzyme immunoassay.
Kupfahl C, Tsikas D, Niemann J, Geginat G, Hof H.
Mol Immunol. 2012 Jan;49(4):621-7. doi: 10.1016/j.molimm.2011.10.010. Epub 2011 Nov 25.

Linkage of bacterial protein synthesis and presentation of MHC class I-restricted Listeria monocytogenes-derived antigenic peptides.
Grauling-Halama S, Schenk S, Bubert A, Geginat G.
PLoS One. 2012;7(3):e33335. doi: 10.1371/journal.pone.0033335. Epub 2012 Mar 12.

Ultra late onset group B streptococcal sepsis with acute renal failure in a child with urethral obstruction: a case report.
Freudenstein D, Reinshagen K, Petzold A, Debus A, Schroten H, Tenenbaum T.
J Med Case Rep. 2012 Feb 20;6:68. doi: 10.1186/1752-1947-6-68.

Chemotaxis of T-cells after infection of human choroid plexus papilloma cells with Echovirus 30 in an in vitro model of the blood-cerebrospinal fluid barrier.
Schneider H, Weber CE, Schoeller J, Steinmann U, Borkowski J, Ishikawa H, Findeisen P, Adams O, Doerries R, Schwerk C, Schroten H, Tenenbaum T.
Virus Res. 2012 Dec;170(1-2):66-74. doi: 10.1016/j.virusres.2012.08.019. Epub 2012 Sep 19.


Toll Toll-like receptors 2 and 4 regulate the frequency of IFNγ-producing CD4+ T-cells during pulmonary infection with Chlamydia pneumoniae.
Wantia N., N. Rodriguez, C. Cirl, T. Ertl, S. Dürr, L.E. Layland, H. Wagner and T. Miethke.
PLoS One. 6:e26101, 2011.

Innate immunity in the male genital tract: Chlamydia trachomatis induces keratinocyte-derived chemokine production in prostate, seminal vesicle and epididymis/vas deferens primary cultures.
Mackern-Oberti, J.P., M. Maccioni, M. L. Breser, A. Eley, T. Miethke and V.E. Rivero.
J. Med. Microbiol.60:307-16, 2011.

Antibiotic prophylaxis in primary and revision hip arthroplasty: what is the evidence?
Gradl, G., C. Horn, L. K. Postl, T. Miethke and H.Gollwitzer.
Orthopade. 40:520-7, 2011.

Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45- cells.
Mackern-Oberti, J. P., M. L. Breser, N. Nuñez, M. Maccioni, N. Rodríguez, N. Wantia, T. Ertl, T. Miethke and V. E. Rivero.
Reproduction 142:427-37, 2011.

Gliotoxin as putative virulence factor and immunotherapeutic target in a cell culture model of cerebral aspergillosis.
Speth C, Kupfahl C, Pfaller K, Hagleitner M, Deutinger M, Würzner R, Mohsenipour I, Lass-Flörl C, Rambach G.
Mol Immunol. 2011 Sep;48(15-16):2122-9. doi: 10.1016/j.molimm.2011.07.005. Epub 2011 Jul 30



Univ. Prof. Dr. med. Thomas Miethke

Direktor des Instituts

Telefon 0621/383-2224
Telefax 0621/383-3816

Universitätsmedizin Mannheim
Theodor-Kutzer-Ufer 1-3
68167 Mannheim