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Ausgewählte Publikationen

2020

Banovic F, Schroten H, Schwerk, C. Potential Roles and Functions of Listerial Virulence Factors during Brain Entry. Toxins. 2020; 12: 297.

Borkowski J, Schroten H, Schwerk C. Interactions and Signal Transduction Pathways Involved during Central Nervous System Entry by Neisseria meningitidis across the Blood-Brain Barriers. Int J Mol Sci. 2020; 21: 8788.

Buchholz B, Niehues T. Lost in Transition A Risk Factor for Mortality in Youth Living With HIV. Pediatr Infect Dis J. 2020; 39: E14-E16.

Denzer L, Schroten H, Schwerk C. From Gene to Protein-How Bacterial Virulence Factors Manipulate Host Gene Expression During Infection. Int J Mol Sci. 2020; 21: 3730.

Derya SM, Spiegel H, Hanisch FG, Morozov V, Schroten H, Jennewein S, Parschat K. Biotechnologically produced fucosylated oligosaccharides inhibit the binding of human noroviruses to their natural receptors. J Biotechnol. 2020; 318: 31-38.

Duarte AC, Rosado T, Costa AR, Santos J, Gallardo E, Quintela T, Ishikawa H, Schwerk C, Schroten H, Goncalves I, Santos CRA. The bitter taste receptor TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier. Biochem Pharmacol. 2020; 117: 113953.

Duarte AC, Santos J, Costa AR, Ferreira CL, Tomas J, Quintela T, Ishikawa H, Schwerk C, Schroten H, Ferrer I, Carro E, Goncalves I, Santos CRA. Bitter taste receptors profiling in the human blood-cerebrospinal fluid-barrier. Biochem Pharmacol. 2020; 177: 113954.

Erb U, Hikel J, Meyer S, Ishikawa H, Worst TS, Nitschke K, Nuhn P, Porubsky S, Weiss C, Schroten H, Adam R, Karremann M. The Impact of Small Extracellular Vesicles on Lymphoblast Trafficking across the Blood-Cerebrospinal Fluid Barrier In Vitro. Int J Mol Sci. 2020; 21: 5491.

Erb U, Schwerk C, Schroten H, Karremann M. Review of functional in vitro models of the blood-cerebrospinal fluid barrier in leukaemia research. J Neurosci Methods. 2020; 329: 108478.

Kim J, Alejandro B, Hetman M, Hattab EM, Joiner J, Schroten H, Ishikawa H, Chung, DH. Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier. Plos Pathog. 2020; 16: e1008204.

Kremer K, Kramer R, Neumann B, Haller S, Pfennigwerth N, Werner G, Gatermann S, Schroten H, Eckmanns T, Hans JB. Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach. Euro Surveill. 2020; 25:.2000923.

Lange B, Tenenbaum T, Wessel LM. COVID-19 Pandemic: Management of pediatric surgical Patients Statement of the German Society for Pediatric Surgery (DGKCH), the German Society of Pediatrics and Adolescent Medicine (DGKJ) and the German Society for pediatric Infectious Diseases (DGPI). Monatsschr Kinderheilkd. 2020; 168: 739-743.

Meurer M, Ohlmann S, Bonilla MC, Valentin-Weigand P, Beineke A, Hennig-Pauka I, Schwerk C, Schroten H, Baums CG, von Kockritz-Blickwede M, de Buhr N. Role of Bacterial and Host DNases on Host-Pathogen Interaction during Streptococcus suis Meningitis; Int J Mol Sci. 2020; 21: 5289.

Morgan SE, Schroten H, Ishikawa H, Zhao NN. Localization of ZIP14 and ZIP8 in HIBCPP Cells. Brain Sci. 2020; 10:534.

Nishihara H, Soldati S, Mossu A, Rosito M, Rudolph H, Muller WA, Latorre D, Sallusto F, Sospedra M, Martin R, Ishikawa H, Tenenbaum T, Schroten H, Gosselet F, Engelhardt B. Human CD4(+) T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro. Fluids Barriers CNS. 2020; 17: 3.

Papan C, Keeren K, Schroten H, Tenenbaum T. Peripheral Facial Nerve Palsy in Children With Enterovirus Infection. Pediatr Infect Dis J. 2020; 39: E327-E329.

Papan C, Willersinn M, Weiss C, Karremann M, Schroten H, Tenenbaum T. Antibiotic utilization in hospitalized children under 2years of age with influenza or respiratory syncytial virus infection - a comparative, retrospective analysis. BMC Infect Dis. 2020; 20: 606.

Rodriguez-Lorenzo S, Francisco DMF, Vos R, van het Hof B, Rijnsburger M, Schroten H, Ishikawa H, Beaino W, Bruggmann R, Kooij G, de Vries HE. Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis. Acta Neuropathol Commun. 2020; 8: 35.

Wegele C, Stump-Guthier C, Moroniak S, Weiss C, Rohde M, Ishikawa H, Schroten H, Schwerk C, Karremann M, Borkowski J. Non-Typeable Haemophilus influenzae Invade Choroid Plexus Epithelial Cells in a Polar Fashion. Int J Mol Sci. 2020; 21: 5739.

Wiatr M, Figueiredo R, Stump-Guthier C, Winter P, Ishikawa H, Adams O, Schwerk C, Schroten H, Rudolph H, Tenenbaum T. Polar Infection of Echovirus-30 Causes Differential Barrier Affection and Gene Regulation at the Blood-Cerebrospinal Fluid Barrier. Int J Mol Sci. 2020; 21: 6268.

Wiatr M, Staubach S, Figueiredo R, Stump-Guthier C, Ishikawa H, Schwerk C, Schroten H, Hanisch FG, Rudolph H, Tenenbaum T. Echovirus-30 Infection Alters Host Proteins in Lipid Rafts at the Cerebrospinal Fluid Barrier In Vitro. Microorganisms. 2020; 8: 1958.

 

2019

Herold R, Schroten H, Schwerk C. Virulence Factors of Meningitis-Causing Bacteria: Enabling Brain Entry across the Blood-Brain Barrier. Int J Mol Sci. 2019; 20:5393.

Koromyslova AD, Morozov VA, Hefele L, Hansman GS. Human Norovirus Neutralized by a Monoclonal Antibody Targeting the Histo-Blood Group Antigen Pocket. J Virol. 2019; 93:e02174-18.

Lauer AN, März M, Meyer S, Meurer M, de Buhr N, Borkowski J, Weiss C, Schroten H, Schwerk, C. Optimized cultivation of porcine choroid plexus epithelial cells, a blood-cerebrospinal fluid barrier model, for studying granulocyte transmigration. Lab Invest. 2019; 99:1245-1255.

Papan C, Kremp L, Weiß C, Petzold A, Schroten H, Tenenbaum T. Infectious causes of peripheral facial nerve palsy in children-a retrospective cohort study with long-term follow-up. Eur J Clin Microbiol Infect Dis. 2019; 38:2177-2184.

Simpson S, Preston D, Schwerk C, Schroten H, Blazer-Yost B. Cytokine and inflammatory mediator effects on TRPV4 function in choroid plexus epithelial cells. Am J Physiol Cell Physiol. 2019; 317:C881-C893.

van Houten CB, Naaktgeboren CA, Ashkenazi-Hoffnung L, Ashkenazi S, Avis W, Chistyakov I, Corigliano T, Galetto A, Gangoiti I, Gervaix A, Glikman D, Ivaskeviciene I, Kuperman AA, Lacroix L, Loeffen Y, Luterbacher F, Meijssen CB, Mintegi S, Nasrallah B, Papan C, van Rossum AMC, Rudolph H, Stein M, Tal R, Tenenbaum T, Usonis V, de Waal W, Weichert S, Wildenbeest JG, de Winter-de Groot KM, Wolfs TFW, Mastboim N, Gottlieb TM, Cohen A, Oved K, Eden E, Feigin PD, Shani L, Bont LJ; IMPRIND consortium. Expert panel diagnosis demonstrated high reproducibility as reference standard in infectious diseases. J Clin Epidemiol. 2019; 112:20-27.

Theile M, Wiora L, Russ D, Reuter J, Ishikawa H, Schwerk C, Schroten H, Mogk S. A Simple Approach to Perform TEER Measurements Using a Self-Made Volt-Amperemeter with Programmable Output Frequency. J Vis Exp. 2019; 152:e60087.

Wiatr M, Stump-Guthier C, Latorre D, Uhlig S, Weiss C, Ilonen J, Engelhardt B, Ishikawa H, Schwerk C, Schroten H, Tenenbaum T, Rudolph H. Distinct migratory pattern of naive and effector T cells through the blood-CSF barrier following Echovirus 30 infection. J. Neuroinflammation. 2019; 16:232.

Yang J, Simonneau C, Kilker R, Oakley L, Byrne MD, Nichtova Z, Stefanescu I, Pardeep-Kumar F, Tripathi S, Londin E, Saugier-Veber P, Willard B, Thakur M, Pickup S, Ishikawa H, Schroten H, Smeyne R, Horowitz A. Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus. EMBO Mol Med. 2019; 11:e9540.

2018

Morozov V, Borkowski J, Hanisch FG. The Double Face of Mucin-Type O-Glycans in Lectin-Mediated Infection and Immunity. Molecules. 2018; 23:E1151

Morozov V, Hanisch FG, Wegner KM, Schroten H. Pandemic GII.4 Sydney and Epidemic GII.17 Kawasaki308 Noroviruses Display Distinct Specificities for Histo-Blood Group Antigens Leading to Different Transmission Vector Dynamics in Pacific Oysters. Front Microbiol. 2018; 9:2826.

Rose R, Häuser S, Stump-Guthier C, Weiss C, Rohde M, Kim KS, Ishikawa H, Schroten H, Schwerk C, Adam R. Virulence factor-dependent basolateral invasion of choroid plexus epithelial cells by pathogenic Escherichia coli in vitro. FEMS Microbiol Lett. 2018; 365:fny274.

Häuser S, Wegele C, Stump-Guthier C, Borkowski J, Weiss C, Rohde M, Ishikawa H, Schroten H, Schwerk C, Adam R. Capsule and fimbriae modulate the invasion of Haemophilus influenzae in a human blood-cerebrospinal fluid barrier model. Int J Med Microbiol. 2018; 308:829-839.

Schillemans M, Karampini E, van den Eshof BL, Gangaev A, Hofman M, van Breevoort D, Meems H, Janssen H, Mulder AA, Jost CR, Escher JC, Adam R, Carter T, Koster AJ, van den Biggelaar M, Voorberg J, Bierings R. Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells. Arterioscler Thromb Vasc Biol. 2018; 38:1549-1561.

März M, Meyer S, Erb U, Georgikou C, Horstmann MA, Hetjens S, Weiß C, Fallier-Becker P, Vandenhaute E, Ishikawa H, Schroten H, Dürken M, Karremann M. Pediatric acute lymphoblastic leukemia-Conquering the CNS across the choroid plexus. Leuk Res. 2018; 71:47-54.

Pfeifer H, Raum K, Markovic S, Nowak V, Fey S, Obländer J, Pressler J, Böhm V, Brüggemann M, Wunderle L, Hüttmann A, Wäsch R, Beck J, Stelljes M, Viardot A, Lang F, Hoelzer D, Hofmann WK, Serve H, Weiss C, Goekbuget N, Ottmann OG, Nowak D. Genomic CDKN2A/2B deletions in adult Ph+ ALL are adverse despite allogeneic stem cell transplantation. Blood. 2018; 131:1464-1475.“

von Bueren AO, Karremann M, Gielen GH, Benesch M, Fouladi M, van Vuurden DG, van Zanten SEMV, Hoffman LM, Kramm CM. A suggestion to introduce the diagnosis of "diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)". Acta Neuropathol. 2018; Jul;136:171-173.

Karremann M, Gielen GH, Hoffmann M, Wiese M, Colditz N, Warmuth-Metz M, Bison B, Claviez A, van Vuurden DG, von Bueren AO, Gessi M, Kühnle I, Hans VH, Benesch M, Sturm D, Kortmann RD, Waha A, Pietsch T, Kramm CM. Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location. Neuro Oncol. 2018; 20:123-131.

Hanisch FG, Hansman GS, Morozov V, Kunz C, Schroten H. Avidity of α-fucose on human milk oligosaccharides and blood group-unrelated oligo/polyfucoses is essential for potent norovirus-binding targets. J Biol Chem. 2018; 293:11955-11965.

Preston D, Simpson S, Halm D, Hochstetler A, Schwerk C, Schroten H, Blazer-Yost BL. Activation of TRPV4 stimulates transepithelial ion flux in a porcine choroid plexus cell line. Am J Physiol Cell Physiol. 2018; 315:C357-C366.

Tenenbaum T, Drechsel-Bäuerle U, Oberle D. Cardiorespiratory Events After Monoclonal Antibody Prophylaxis With Palivizumab. Pediatr Infect Dis J. 2018; 11:e281-e282.

Dahm T, Adams O, Boettcher S, Diedrich S, Morozov V, Hansman G, Fallier-Becker P, Schädler S, Burkhardt CJ, Weiss C, Stump-Guthier C, Ishikawa H, Schroten H, Schwerk C, Tenenbaum T, Rudolph H. Strain-dependent effects of clinical echovirus 30 outbreak isolates at the blood-CSF barrier. J Neuroinflammation. 2018; 15:50.

Morozov V, Hansman G, Hanisch FG, Schroten H, Kunz C. Human Milk Oligosaccharides as Promising Antivirals. Mol Nutr Food Res. 2018; 62:e1700679.

Lauer AN, Tenenbaum T, Schroten H, Schwerk C. The diverse cellular responses of the choroid plexus during infection of the central nervous system. Am J Physiol Cell Physiol. 2018; 314:C152-C165.

Papan C, Meyer-Buehn M, Laniado G, Nicolai T, Griese M, Huebner J. Assessment of the multiplex PCR-based assay Unyvero pneumonia application for detection of bacterial pathogens and antibiotic resistance genes in children and neonates. Infection. 2018; 46:189-196.

2017

Almamy A, Schwerk C, Schroten H, Ishikawa H, Asif AR, Reuss B. Interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line. Immunol Res. 2017; 65:1110-1123.

Eichinger M, Schneider S, De Bock F. Subjectively and objectively assessed social and physical environmental correlates of preschoolers' accelerometer-based physical activity. Int J Behav Nutr Phys Act. 2017; 14:153.

Schwerk C. Muramidase-released protein of Streptococcus suis: New insight into its impact on virulence. Virulence. 2017; 8:1078-1080.

Rudolph H, Prieto Dernbach R, Walka M, Rey-Hinterkopf P, Melichar V, Muschiol E, Schweitzer-Krantz S, Richter JW, Weiss C, Böttcher S, Diedrich S, Schroten H, Tenenbaum T. Comparison of clinical and laboratory characteristics during two major paediatric meningitis outbreaks of echovirus 30 and other non-polio enteroviruses in Germany in 2008 and 2013. Eur J Clin Microbiol Infect Dis. 2017; 36:1651-1660.

Nau J, Eller SK, Wenning J, Spekker-Bosker KH, Schroten H, Schwerk C, Hotop A, Groß U, Däubener W. Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis. Mediators Inflamm. 2017; 2017:3260289.

Koromyslova A, Tripathi S, Morozov V, Schroten H, Hansman GS. Human norovirus inhibition by a human milk oligosaccharide. Virology. 2017; 508:81-89.

Karremann M, Krämer N, Hoffmann M, Wiese M, Beilken A, Corbacioglu S, Dilloo D, Driever PH, Scheurlen W, Kulozik A, Gielen GH, von Bueren AO, Dürken M, Kramm CM. Haematological malignancies following temozolomide treatment for paediatric high-grade glioma. Eur J Cancer. 2017; 81:1-8.

Feldner A, Adam MG, Tetzlaff F, Moll I, Komljenovic D, Sahm F, Bäuerle T, Ishikawa H, Schroten H, Korff T, Hofmann I, Wolburg H, von Deimling A, Fischer A. Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med. 2017; 9:890-905.

Almamy A, Schwerk C, Schroten H, Ishikawa H, Asif, AR, Reuss, B. Crossreactivity of an Antiserum Directed to the Gram-Negative Bacterium Neisseria gonorrhoeae with the SNARE-Complex Protein Snap23 Correlates to Impaired Exocytosis in SH-SY5Y Cells. J Mol Neurosci. 2017; 62:163-180.

Doerflinger SY, Weichert S, Koromyslova A, Chan M, Schwerk C, Adam R, Jennewein S, Hansman GS, Schroten H. Human Norovirus Evolution in a Chronically Infected Host. mSphere. 2017; 2:pii:e00352-16.

Dahm T, Frank F, Adams O, Lindner HA, Ishikawa H, Weiss C, Schwerk C, Schroten H, Tenenbaum T, Rudolph H. Sequential transmigration of polymorphonuclear cells and naive CD3+ T lymphocytes across the blood-cerebrospinal-fluid barrier in vitro following infection with Echovirus 30. Virus Res. 2017; 232:54-62.

de Buhr N, Reuner F, Neumann A, Stump-Guthier C, Tenenbaum T, Schroten H, Ishikawa H, Müller K, Beineke A, Hennig-Pauka I, Gutsmann T, Valentin-Weigand P, Baums CG, von Köckritz-Blickwede M . Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment. Cell Microbiol. 2017; 19:e12649.

Dinner S, Kaltschmidt J, Stump-Guthier C, Hetjens S, Ishikawa H, Tenenbaum T, Schroten H, Schwerk C. Mitogen-activated protein kinases are required for effective infection of human choroid plexus epithelial cells by Listeria monocytogenes. Microbes Infect. 2017; 19:18-33.

Rettinger E, Merker M, Salzmann-Manrique E, Kreyenberg H, Krenn T, Dürken M, Faber J, Huenecke S, Cappel C, Bremm M, Willasch A, Bakhtiar S, Jarisch A, Soerensen J, Klingebiel T, Bader P. Pre-Emptive Immunotherapy for Clearance of Molecular Disease in Childhood Acute Lymphoblastic Leukemia after Transplantation. Biol Blood Marrow Transplant. 2017; 23:87-95.

2016

Reuss B, Asif AR, Almamy A, Schwerk C, Schroten H, Ishikawa H, Drummer C, Behr R. Antisera against Neisseria gonorrhoeae cross-react with specific brain proteins of the common marmoset monkey and other nonhuman primate species. Brain Res. 2016; 1653:23-38.

Tenenbaum T, Becker KP, Lange B, Martin A, Schäfer P, Weichert S, Schroten H. Prevalence of Multidrug-Resistant Organisms in Hospitalized Pediatric Refugees in an University Children's Hospital in Germany 2015-2016. Infect Control Hosp Epidemiol. 2016; 37:1310-1314.

Dotz V, Adam R, Lochnit G, Schroten H, Kunz C. Neutral oligosaccharides in feces of breastfed and formula-fed infants at different ages. Glycobiology. 2016; 26:1308-1316.

de Buhr N, Reuner F, Neumann A, Stump-Guthier C, Tenenbaum T, Schroten H, Ishikawa H, Müller K, Beineke A, Hennig-Pauka I, Gutsmann T, Valentin-Weigand P, Baums CG, von Köckritz-Blickwede M. Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment. Cell Microbiol. 2016; Epub ahead of print.

Shen Z, Liu Y, Dewidar B, Hu J, Park O, Feng T, Xu C, Yu C, Li Q, Meyer C, Ilkavets I, Müller A, Stump-Guthier C, Munker S, Liebe R, Zimmer V, Lammert F, Mertens PR, Li H, Ten Dijke P, Augustin HG, Li J, Gao B, Ebert MP, Dooley S, Li Y, Weng HL. Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression. Am J Pathol. 2016; Epub ahead of print.

Tenenbaum T, Seitz M, Schroten H, Schwerk C. Biological activities of suilysin: role in Streptococcus suis pathogenesis. Future Microbiol. 2016; 11:941-954.

Rudolph H, Klopstein A, Gruber I, Blatti C, Lyck R, Engelhardt B. Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro. Eur J Immunol. 2016; 46:2187-2203.

Dahm T, Rudolph H, Schwerk C, Schroten H, Tenenbaum T. Neuroinvasion and Inflammation in Viral Central Nervous System Infections. Mediators Inflamm. 2016; 2016:8562805.

Dinner S, Borkowski J, Stump-Guthier C, Ishikawa H, Tenenbaum T, Schroten H, Schwerk C. A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side. J Vis Exp. 2016; 111.

Schroten H, Hanisch FG, Hansman GS. Human Norovirus Interactions with Histo-Blood Group Antigens and Human Milk Oligosaccharides. J Virol. 2016; 90: 5855-5859.

Weichert S, Koromyslova A, Singh BK, Hansman S, Jennewein S, Schroten H, Hansman GS. Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides. J Virol. 2016; 90:4843-4848.

Rudolph H, Schroten H, Tenenbaum T. Enterovirus Infections of the Central Nervous System in Children: An Update. Pediatr Infect Dis J. 2016; 35:567-569.

Oberle D, Pavel J, Rieck T, Weichert S, Schroten H, Keller-Stanislawski B, Tenenbaum T. Anaphylaxis After Immunization of Children and Adolescents in Germany. Pediatr Infect Dis J. 2016; 35:535-541.

Kowalzik F, Zepp F, Hoffmann I, Binder H, Lautz D, van Ewijk R, Knuf M, Tenenbaum T, Laass M, Reuter T, Schulze-Rath R, Marron M. Disease Burden of Rotavirus Gastroenteritis in Children Residing in Germany: A Retrospective, Hospital-based Surveillance. Pediatr Infect Dis J. 2016; 35:97-103.

Tenenbaum T, Niessen J, Schroten H. Severe Upper Extremity Dysfunction After 4CMenB Vaccination in a Young Infant. Pediatr Infect Dis J. 2016; 35:94-96.

Vogel M, Grund S, Pandey S, Mayatepek E, Schroten H, Tenenbaum T, Adams O. What We Have Learned from the Influenza A pH1N1 2009/10 Pandemic: High Clinical Impact of Human Metapneumovirus and Respiratory Syncytial Virus in Hospitalized Pediatric Patients. Jpn J Infect Dis. 2016; 69:6-11.