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Angiodiversity and organotropic metastasis

The concept of a unidirectional cascade of metastatic events has been replaced in recent years by the metastatic cycle - the concept of a dynamic feed forward cycle of metastatic niches that evolve upon reciprocal interactions with the primary tumor and disseminating cancer cells. Primary tumors interact with pre-metastatic sites preparing organ-specific pre-metastatic niches. Metastasis-initiating cells home to and succumb to interactions with developing organ-specific metastatic niches, and secondary recirculating cancer cells interact back with the primary. Metastatic tropism as well as metastatic disease progression are a result of this feed forward cycle of dynamic, reciprocal interactions of cancer cells with their diverse metastatic niches. A better understanding of the multifaceted contributions of the organ-specific metastatic niches and their complex changes on cancer cell dissemination and of the mutual effects of the cellular and molecular mechanisms involved will open new avenues to better therapies for hitherto intractable progressive disease states of cancer patients and for adjuvant treatment options preventing relapses in tumor-free patients. Recent experiments have indicated that Notch signaling may be involved in organotropic metastatic processes to the lung and to the liver.

 

The hepatic vascular niche in melanoma metastasis: liver sinusoidal endothelial-specific adhesion molecules / scavenger receptors (Stab1, Stab2, CD32b, MRC1, CLEG4G, CLEC4M, CLEC1B) and LSEC-specific angiokines (Wnt2, HGF)

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Ärztliche Leitung

Philipp-Sebastian Koch

PD Dr. med. Philipp Reiners-Koch

Oberarzt

Stellvertretender Leiter der operativen Dermatologie

Facharzt für Haut- und
Geschlechtskrankheiten

Telefon 0621/383-2282
Telefax 0621/383-3815

philipp.koch@remove-this.umm.de

Prof. Dr. S. Goerdt

Prof. Dr. med. Sergij Goerdt

Direktor der Klinik

Facharzt für Haut- und
Geschlechtskrankheiten
Allergologie
Dermatohistologie

Praktika & Abschlussarbeiten

Bei Interesse an der Mitarbeit an einem unserer Forschungsprojekte wenden Sie sich bitte an Prof. Dr. med. Sergij Goerdt  oder Dr. med. Philipp Reiners-Koch. Es besteht die Möglichkeit der Absolvierung eines Laborpraktikums, der Anfertigung einer Diplom- bzw. Masterarbeit sowie die Durchführung einer medizinischen bzw. naturwissenschaftlichen Doktorarbeit.