Sie befinden sich hier




Heil J, Olsavszky V, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS. (2021)  Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat Commun. 12(1):6963.

Koch PS, Sandorski K*, Heil J, Schmid CD, Kürschner SW, Hoffmann J, Winkler M, Staniczek T, de la Torre C, Sticht C, Schledzewski K, Taketo MM, Trogisch FA, Heineke J, Géraud C, Goerdt S, Olsavszky V. (2021) Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation. Front Physiol.12:722394. 

Olsavszky V, Sticht C, Schmid CD, Winkler M, Wohlfeil SA, Olsavszky A, Schledzewski K, Geraud C, Goerdt S, Leibing T, Koch PS (2021) Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells. Gene 768: 145284

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S (2021) Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. Journal of hepatology 74: 380-393


Winkler M, Biswas S, Berger SM, Kuchler M, Preisendorfer L, Choo M, Fruh S, Rem PD, Enkel T, Arnold B, Komljenovic D, Sticht C, Goerdt S, Bettler B, von Bohlen Und Halbach O, Bartsch D, Geraud C (2020) Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior. Molecular psychiatry 25: 2979-2993


Wohlfeil SA*, Häfele V*, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Mohammadi MM, Heineke J, Sticht C, Olsavszky V, Koch PS, Géraud C, Goerdt S. (2019) Hepatic Endothelial Notch Activation Protects against Liver Metastasis by Regulating Endothelial-Tumor Cell Adhesion Independent of Angiocrine Signaling. Cancer Res. 79(3):598-610. doi: 10.1158/0008-5472.CAN-18-1752.


Leibing T, Geraud C, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS (2018) Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology 68: 707-722

Schmid CD, Schledzewski K, Mogler C, Waldburger N, Kalna V, Marx A, Randi AM, Geraud C, Goerdt S, Koch PS (2018) GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro. Biochemical and biophysical research communications 497: 32-38


Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S (2017) Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. The Journal of Clinical Investigation 127: 1099-1114.

Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantzi H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS. (2017) GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene 627: 491-499.

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C* (2017) Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 29: 415-9.


Nicolay JP, Felcht M, Schledzewski K, Goerdt S, Géraud C (2016) Sézary syndrome: old enigmas, new targets. JDDG 14(3):256-6.

Evdokimov K, Biswas S, Schledzewski K, Winkler M, Gorzelanny C, Schneider SW, Goerdt S, Géraud C (2016) Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing. Biochem Biophys Res Commun 475(4):342-9.


Biswas S, Adrian M, Evdokimov K, Schledzewski K, Weber J, Winkler M, Goerdt S, Géraud C (2015) Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages. Biochem Biophys Res Commun 464(4): 1078-83


Runge A, Hu J, Wieland M, Bergeest JP, Mogler C, Neumann A, Géraud C, Arnold B, Rohr K, Komljenovic D, Schirmacher P, Goerdt S, Augustin HG (2014) An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice. Cancer Research 74: 4157-4169

Géraud C, Koch PS, Damm F, Schledzewski K, Goerdt S (2014) The metastatic cycle: metastatic niches and cancer cell dissemination. JDDG 12: 1012-9

Géraud C, Koch PS, Goerdt S (2014) Vascular niches: endothelial cells as tissue- and site-specific multifunctional team players in health and disease. JDDG 12: 685-9


Géraud C, Mogler C, Runge A, Evdokimov K, Lu S, Schledzewski K, Arnold B, Hammerling G, Koch PS, Breuhahn K, Longerich T, Marx A, Weiss C, Damm F, Schmieder A, Schirmacher P, Augustin HG, Goerdt S (2013) Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival. Liver International 33: 1428-1440

Evdokimov K, Biswas S, Adrian M, Weber J, Schledzewski K, Winkler M, Goerdt S, Géraud C (2013) Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization. Biochem Biophys Res Commun 434: 22-27


Géraud C, Evdokimov K, Straub BK, Peitsch WK, Demory A, Dorflinger Y, Schledzewski K, Schmieder A, Schemmer P, Augustin HG, Schirmacher P, Goerdt S (2012) Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. PloS One 7: e34206


Schledzewski K*, Géraud C*, Arnold B, Wang S, Grone HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, Schonhaber H, Gratchev A, Dietz L, Thierse HJ, Kzhyshkowska J, Goerdt S (2011) Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. The Journal of Clinical Investigation 121: 703-714


Géraud C, Schledzewski K, Demory A, Klein D, Kaus M, Peyre F, Sticht C, Evdokimov K, Lu S, Schmieder A, Goerdt S (2010) Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Hepatology 52: 313-326

Biolac-Sage P, Lepreux S, Schledzewski K, Cubel G, Géraud C, Goerdt S, Balabaud C (2010) Identification of liver sinusoidal endothelial cells in the human liver. Liver international 30: 773-776


Klein D, Demory A, Peyre F, Kroll J, Géraud C, Ohnesorge N, Schledzewski K, Arnold B, Goerdt S (2009) Wnt2 acts as an angiogenic growth factor for non-sinusoidal endothelial cells and inhibits expression of stanniocalcin-1. Angiogenesis 12: 251-265  

Zhang J, Gratchev A, Riabov V, Mamidi S, Schmuttermaier C, Krusell L, Kremmer E, Workman G, Sage EH, Jalkanen S, Goerdt S, Kzhyshkowska J (2009) A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1. Mol Cell Biol 29(22): 6097-105


Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J,  Schledzewski K, Arnold B, Goerdt S (2008) Wnt2 acts as a cell type-specific, autocrine  growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology 47: 1018-31.


Kzhyshkowska J, Mamidi S, Gratchev A, Kremmer E, Schmuttermaier C, Krusell L, Haus G, Utikal J, Schledzewski K, Scholtze J, Goerdt S (2006) Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood 107: 3221-8

Schledzewski K, Falkowski M, Moldenhauer G, Metharom P, Kzhyshkowska J, Ganss  R, Demory A, Falkowska-Hansen B, Kurzen H, Ugurel S, Geginat G, Arnold B, Goerdt  S (2006) Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis. J Pathol 209: 67-77.  

Martens JH, Kzhyshkowska J, Falkowski-Hansen M, Schledzewski K, Gratchev A, Mansmann U, Schmuttermaier C, Dippel E, Koenen W, Riedel F, Sankala M, Tryggvason K, Kobzik L, Moldenhauer G, Arnold B, Goerdt S (2006) Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in  human lymph node sinuses, the primary sites of regional metastasis. J Pathol 208: 574-89.


Hansen B, Longati P, Elvevold K, Nedredal GI, Schledzewski K, Olsen R, Falkowski M, Kzhyshkowska J, Carlsson F, Johansson S, Smedsrød B, Goerdt S, Johansson S, McCourt P (2005) Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding. Exp Cell Res 303: 160-73.


Kzhyshkowska J, Gratchev A, Martens JH, Pervushina O, Mamidi S, Johansson S, Schledzewski K, Hansen B, He X, Tang J, Nakayama K, Goerdt S (2004) Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. J Leukoc Biol 76: 1151-61.  

McCourt PA, Hansen B, Svistuonov D, Johansson S, Longati P, Schledzewski K, Kzhyshkowska J, Goerdt S, Johansson S, Smedsrød B (2004) The liver sinusoidal endothelial cell hyaluronan receptor and its homolog, stabilin-1 - Their roles (known and unknown) in endocytosis. Comp Hepatol 3 Suppl 1: S24.


Falkowski M, Schledzewski K, Hansen B, Goerdt S (2003) Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces. Histochem Cell Biol 120: 361-9.


Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson  S, Goerdt S (2002) Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J 362:155-64.


Ärztliche Leitung

Philipp-Sebastian Koch

PD Dr. med. Philipp Reiners-Koch


Stellvertretender Leiter der operativen Dermatologie

Leiter der Ästhetischen Dermatologie

Facharzt für Haut- und

Telefon 0621/383-2282
Telefax 0621/383-3815

Prof. Dr. S. Goerdt

Prof. Dr. med. Sergij Goerdt

Direktor der Klinik

Facharzt für Haut- und

Praktika & Abschlussarbeiten

Bei Interesse an der Mitarbeit an einem unserer Forschungsprojekte wenden Sie sich bitte an Prof. Dr. med. Sergij Goerdt  oder Dr. med. Philipp Reiners-Koch. Es besteht die Möglichkeit der Absolvierung eines Laborpraktikums, der Anfertigung einer Diplom- bzw. Masterarbeit sowie die Durchführung einer medizinischen bzw. naturwissenschaftlichen Doktorarbeit.