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Publikationen

2022

Wohlfeil, S. A.; Häfele, V.; Dietsch, B.; Weller, C.; Sticht, C.; Jauch, A. S.; Winkler, M.; Schmid, C. D.; Irkens, A. L.; Olsavszky, A.; Schledzewski, K.; Reiners-Koch, P.-S.; Goerdt, S.; Géraud, C. Angiogenic and Molecular Diversity Determine Hepatic Melanoma Metastasis and Response to Anti-Angiogenic Treatment. J Transl Med 2022, 20 (1), 62. https://doi.org/10.1186/s12967-022-03255-4.

Schmid, C. D.; Olsavszky, V.; Reinhart, M.; Weyer, V.; Trogisch, F. A.; Sticht, C.; Winkler, M.; Kürschner, S. W.; Hoffmann, J.; Ola, R.; Staniczek, T.; Heineke, J.; Straub, B. K.; Mittler, J.; Schledzewski, K.; Ten Dijke, P.; Richter, K.; Dooley, S.; Géraud, C.; Goerdt, S.; Koch, P.-S. ALK1 Controls Hepatic Vessel Formation, Angiodiversity, and Angiocrine Functions in Hereditary Hemorrhagic Telangiectasia of the Liver. Hepatology 2022. https://doi.org/10.1002/hep.32641.

2021

Winkler, M.; Staniczek, T.; Kürschner, S. W.; Schmid, C. D.; Schönhaber, H.; Cordero, J.; Kessler, L.; Mathes, A.; Sticht, C.; Neßling, M.; Uvarovskii, A.; Anders, S.; Zhang, X.-J.; von Figura, G.; Hartmann, D.; Mogler, C.; Dobreva, G.; Schledzewski, K.; Géraud, C.; Koch, P.-S.; Goerdt, S. Endothelial GATA4 Controls Liver Fibrosis and Regeneration by Preventing a Pathogenic Switch in Angiocrine Signaling. J Hepatol 2021, 74 (2), 380–393. https://doi.org/10.1016/j.jhep.2020.08.033.

Olsavszky, V.; Sticht, C.; Schmid, C. D.; Winkler, M.; Wohlfeil, S. A.; Olsavszky, A.; Schledzewski, K.; Géraud, C.; Goerdt, S.; Leibing, T.; Koch, P.-S. Exploring the Transcriptomic Network of Multi-Ligand Scavenger Receptor Stabilin-1- and Stabilin-2-Deficient Liver Sinusoidal Endothelial Cells. Gene 2021, 768, 145284. https://doi.org/10.1016/j.gene.2020.145284.

Koch, P.-S.; Sandorski, K.; Heil, J.; Schmid, C. D.; Kürschner, S. W.; Hoffmann, J.; Winkler, M.; Staniczek, T.; de la Torre, C.; Sticht, C.; Schledzewski, K.; Taketo, M. M.; Trogisch, F. A.; Heineke, J.; Géraud, C.; Goerdt, S.; Olsavszky, V. Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation. Front Physiol 2021, 12, 722394. https://doi.org/10.3389/fphys.2021.722394.

Koch, P.-S.; Lee, K. H.; Goerdt, S.; Augustin, H. G. Angiodiversity and Organotypic Functions of Sinusoidal Endothelial Cells. Angiogenesis 2021, 24 (2), 289–310. https://doi.org/10.1007/s10456-021-09780-y.

Heil, J.; Olsavszky, V.; Busch, K.; Klapproth, K.; de la Torre, C.; Sticht, C.; Sandorski, K.; Hoffmann, J.; Schönhaber, H.; Zierow, J.; Winkler, M.; Schmid, C. D.; Staniczek, T.; Daniels, D. E.; Frayne, J.; Metzgeroth, G.; Nowak, D.; Schneider, S.; Neumaier, M.; Weyer, V.; Groden, C.; Gröne, H.-J.; Richter, K.; Mogler, C.; Taketo, M. M.; Schledzewski, K.; Géraud, C.; Goerdt, S.; Koch, P.-S. Bone Marrow Sinusoidal Endothelium Controls Terminal Erythroid Differentiation and Reticulocyte Maturation. Nat Commun 2021, 12 (1), 6963. https://doi.org/10.1038/s41467-021-27161-3.

2020

Zhang, X.-J.; Olsavszky, V.; Yin, Y.; Wang, B.; Engleitner, T.; Öllinger, R.; Schledzewski, K.; Koch, P.-S.; Rad, R.; Schmid, R. M.; Friess, H.; Goerdt, S.; Hüser, N.; Géraud, C.; von Figura, G.; Hartmann, D. Angiocrine Hepatocyte Growth Factor Signaling Controls Physiological Organ and Body Size and Dynamic Hepatocyte Proliferation to Prevent Liver Damage during Regeneration. Am J Pathol 2020, 190 (2), 358–371. https://doi.org/10.1016/j.ajpath.2019.10.009.

Winkler, M.; Biswas, S.; Berger, S. M.; Küchler, M.; Preisendörfer, L.; Choo, M.; Früh, S.; Rem, P. D.; Enkel, T.; Arnold, B.; Komljenovic, D.; Sticht, C.; Goerdt, S.; Bettler, B.; von Bohlen und Halbach, O.; Bartsch, D.; Géraud, C. Pianp Deficiency Links GABAB Receptor Signaling and Hippocampal and Cerebellar Neuronal Cell Composition to Autism-like Behavior. Mol. Psychiatry 2020, 25 (11), 2979–2993. https://doi.org/10.1038/s41380-019-0519-9.

2019

Wohlfeil, S. A.; Häfele, V.; Dietsch, B.; Schledzewski, K.; Winkler, M.; Zierow, J.; Leibing, T.; Mohammadi, M. M.; Heineke, J.; Sticht, C.; Olsavszky, V.; Koch, P.-S.; Géraud, C.; Goerdt, S. Hepatic Endothelial Notch Activation Protects against Liver Metastasis by Regulating Endothelial-Tumor Cell Adhesion Independent of Angiocrine Signaling. Cancer Res. 2019, 79 (3), 598–610. https://doi.org/10.1158/0008-5472.CAN-18-1752.

2018

Schmid, C. D.; Schledzewski, K.; Mogler, C.; Waldburger, N.; Kalna, V.; Marx, A.; Randi, A. M.; Géraud, C.; Goerdt, S.; Koch, P.-S. GPR182 Is a Novel Marker for Sinusoidal Endothelial Differentiation with Distinct GPCR Signaling Activity in Vitro. Biochem. Biophys. Res. Commun. 2018, 497 (1), 32–38. https://doi.org/10.1016/j.bbrc.2018.01.185.

Leibing, T.; Géraud, C.; Augustin, I.; Boutros, M.; Augustin, H. G.; Okun, J. G.; Langhans, C.-D.; Zierow, J.; Wohlfeil, S. A.; Olsavszky, V.; Schledzewski, K.; Goerdt, S.; Koch, P.-S. Angiocrine Wnt Signaling Controls Liver Growth and Metabolic Maturation in Mice. Hepatology 2018, 68 (2), 707–722. https://doi.org/10.1002/hep.29613.

2017

Olsavszky, V.; Ulbrich, F.; Singh, S.; Diett, M.; Sticht, C.; Schmid, C. D.; Zierow, J.; Wohlfeil, S. A.; Schledzewski, K.; Dooley, S.; Gaitantzi, H.; Breitkopf-Heinlein, K.; Géraud, C.; Goerdt, S.; Koch, P.-S. GATA4 and LMO3 Balance Angiocrine Signaling and Autocrine Inflammatory Activation by BMP2 in Liver Sinusoidal Endothelial Cells. Gene 2017, 627, 491–499. https://doi.org/10.1016/j.gene.2017.06.051.

Koch, P.-S.; Olsavszky, V.; Ulbrich, F.; Sticht, C.; Demory, A.; Leibing, T.; Henzler, T.; Meyer, M.; Zierow, J.; Schneider, S.; Breitkopf-Heinlein, K.; Gaitantzi, H.; Spencer-Dene, B.; Arnold, B.; Klapproth, K.; Schledzewski, K.; Goerdt, S.; Géraud, C. Angiocrine Bmp2 Signaling in Murine Liver Controls Normal Iron Homeostasis. Blood 2017, 129 (4), 415–419. https://doi.org/10.1182/blood-2016-07-729822.

Géraud, C.; Koch, P.-S.; Zierow, J.; Klapproth, K.; Busch, K.; Olsavszky, V.; Leibing, T.; Demory, A.; Ulbrich, F.; Diett, M.; Singh, S.; Sticht, C.; Breitkopf-Heinlein, K.; Richter, K.; Karppinen, S.-M.; Pihlajaniemi, T.; Arnold, B.; Rodewald, H.-R.; Augustin, H. G.; Schledzewski, K.; Goerdt, S. GATA4-Dependent Organ-Specific Endothelial Differentiation Controls Liver Development and Embryonic Hematopoiesis. J. Clin. Invest. 2017, 127 (3), 1099–1114. https://doi.org/10.1172/JCI90086.

2016

Evdokimov, K.; Biswas, S.; Schledzewski, K.; Winkler, M.; Gorzelanny, C.; Schneider, S. W.; Goerdt, S.; Géraud, C. Leda-1/Pianp Is Targeted to the Basolateral Plasma Membrane by a Distinct Intracellular Juxtamembrane Region and Modulates Barrier Properties and E-Cadherin Processing. Biochem. Biophys. Res. Commun. 2016, 475 (4), 342–349. https://doi.org/10.1016/j.bbrc.2016.05.092.

Biswas, S.; Adrian, M.; Weber, J.; Evdokimov, K.; Winkler, M.; Géraud, C. Posttranslational Proteolytic Processing of Leda-1/Pianp Involves Cleavage by MMPs, ADAM10/17 and Gamma-Secretase. Biochem. Biophys. Res. Commun. 2016, 477 (4), 661–666. https://doi.org/10.1016/j.bbrc.2016.06.116.

2015

Biswas, S.; Adrian, M.; Evdokimov, K.; Schledzewski, K.; Weber, J.; Winkler, M.; Goerdt, S.; Géraud, C. Counter-Regulation of the Ligand-Receptor Pair Leda-1/Pianp and Pilrα during the LPS-Mediated Immune Response of Murine Macrophages. Biochem. Biophys. Res. Commun. 2015, 464 (4), 1078–1083. https://doi.org/10.1016/j.bbrc.2015.07.079.

2014

Runge, A.; Hu, J.; Wieland, M.; Bergeest, J.-P.; Mogler, C.; Neumann, A.; Géraud, C.; Arnold, B.; Rohr, K.; Komljenovic, D.; Schirmacher, P.; Goerdt, S.; Augustin, H. G. An Inducible Hepatocellular Carcinoma Model for Preclinical Evaluation of Antiangiogenic Therapy in Adult Mice. Cancer Res 2014, 74 (15), 4157–4169. https://doi.org/10.1158/0008-5472.CAN-13-2311.

Géraud, C.; Koch, P.-S.; Goerdt, S. Vascular Niches: Endothelial Cells as Tissue- and Site-Specific Multifunctional Team Players in Health and Disease. J Dtsch Dermatol Ges 2014, 12 (8), 685–689. https://doi.org/10.1111/ddg.12402.

Géraud, C.; Koch, P. S.; Damm, F.; Schledzewski, K.; Goerdt, S. The Metastatic Cycle: Metastatic Niches and Cancer Cell Dissemination. J Dtsch Dermatol Ges 2014, 12 (11), 1012–1019. https://doi.org/10.1111/ddg.12451.

2013

Géraud, C.; Mogler, C.; Runge, A.; Evdokimov, K.; Lu, S.; Schledzewski, K.; Arnold, B.; Hämmerling, G.; Koch, P. S.; Breuhahn, K.; Longerich, T.; Marx, A.; Weiss, C.; Damm, F.; Schmieder, A.; Schirmacher, P.; Augustin, H. G.; Goerdt, S. Endothelial Transdifferentiation in Hepatocellular Carcinoma: Loss of Stabilin-2 Expression in Peri-Tumourous Liver Correlates with Increased Survival. Liver Int. 2013, 33 (9), 1428–1440. https://doi.org/10.1111/liv.12262.

Evdokimov, K.; Biswas, S.; Adrian, M.; Weber, J.; Schledzewski, K.; Winkler, M.; Goerdt, S.; Géraud, C. Proteolytic Cleavage of LEDA-1/PIANP by Furin-like Proprotein Convertases Precedes Its Plasma Membrane Localization. Biochem. Biophys. Res. Commun. 2013, 434 (1), 22–27. https://doi.org/10.1016/j.bbrc.2013.03.073.

2012

Géraud, C.; Evdokimov, K.; Straub, B. K.; Peitsch, W. K.; Demory, A.; Dörflinger, Y.; Schledzewski, K.; Schmieder, A.; Schemmer, P.; Augustin, H. G.; Schirmacher, P.; Goerdt, S. Unique Cell Type-Specific Junctional Complexes in Vascular Endothelium of Human and Rat Liver Sinusoids. PLoS ONE 2012, 7 (4), e34206. https://doi.org/10.1371/journal.pone.0034206.

2011

Schledzewski, K.; Géraud, C.; Arnold, B.; Wang, S.; Gröne, H.-J.; Kempf, T.; Wollert, K. C.; Straub, B. K.; Schirmacher, P.; Demory, A.; Schönhaber, H.; Gratchev, A.; Dietz, L.; Thierse, H.-J.; Kzhyshkowska, J.; Goerdt, S. Deficiency of Liver Sinusoidal Scavenger Receptors Stabilin-1 and -2 in Mice Causes Glomerulofibrotic Nephropathy via Impaired Hepatic Clearance of Noxious Blood Factors. J. Clin. Invest. 2011, 121 (2), 703–714. https://doi.org/10.1172/JCI44740.

2010

Géraud, C.; Schledzewski, K.; Demory, A.; Klein, D.; Kaus, M.; Peyre, F.; Sticht, C.; Evdokimov, K.; Lu, S.; Schmieder, A.; Goerdt, S. Liver Sinusoidal Endothelium: A Microenvironment-Dependent Differentiation Program in Rat Including the Novel Junctional Protein Liver Endothelial Differentiation-Associated Protein-1. Hepatology 2010, 52 (1), 313–326. https://doi.org/10.1002/hep.23618.

Bioulac-Sage, P.; Lepreux, S.; Schledzewski, K.; Cubel, G.; Géraud, C.; Goerdt, S.; Balabaud, C. Identification of Liver Sinusoidal Endothelial Cells in the Human Liver. Liver Int 2010, 30 (5), 773–776. https://doi.org/10.1111/j.1478-3231.2010.02222.x.

2009

Zhang, J.; Gratchev, A.; Riabov, V.; Mamidi, S.; Schmuttermaier, C.; Krusell, L.; Kremmer, E.; Workman, G.; Sage, E. H.; Jalkanen, S.; Goerdt, S.; Kzhyshkowska, J. A Novel GGA-Binding Site Is Required for Intracellular Sorting Mediated by Stabilin-1. Mol Cell Biol 2009, 29 (22), 6097–6105. https://doi.org/10.1128/MCB.00505-09.

Klein, D.; Demory, A.; Peyre, F.; Kroll, J.; Géraud, C.; Ohnesorge, N.; Schledzewski, K.; Arnold, B.; Goerdt, S. Wnt2 Acts as an Angiogenic Growth Factor for Non-Sinusoidal Endothelial Cells and Inhibits Expression of Stanniocalcin-1. Angiogenesis 2009, 12 (3), 251–265. https://doi.org/10.1007/s10456-009-9145-5.

2008

Klein, D.; Demory, A.; Peyre, F.; Kroll, J.; Augustin, H. G.; Helfrich, W.; Kzhyshkowska, J.; Schledzewski, K.; Arnold, B.; Goerdt, S. Wnt2 Acts as a Cell Type-Specific, Autocrine Growth Factor in Rat Hepatic Sinusoidal Endothelial Cells Cross-Stimulating the VEGF Pathway. Hepatology 2008, 47 (3), 1018–1031. https://doi.org/10.1002/hep.22084.

2006

Kzhyshkowska J, Mamidi S, Gratchev A, Kremmer E, Schmuttermaier C, Krusell L, Haus G, Utikal J, Schledzewski K, Scholtze J, Goerdt S (2006) Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood 107: 3221-8

Schledzewski K, Falkowski M, Moldenhauer G, Metharom P, Kzhyshkowska J, Ganss  R, Demory A, Falkowska-Hansen B, Kurzen H, Ugurel S, Geginat G, Arnold B, Goerdt  S (2006) Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis. J Pathol 209: 67-77.  

Martens JH, Kzhyshkowska J, Falkowski-Hansen M, Schledzewski K, Gratchev A, Mansmann U, Schmuttermaier C, Dippel E, Koenen W, Riedel F, Sankala M, Tryggvason K, Kobzik L, Moldenhauer G, Arnold B, Goerdt S (2006) Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in  human lymph node sinuses, the primary sites of regional metastasis. J Pathol 208: 574-89.

2005

Hansen B, Longati P, Elvevold K, Nedredal GI, Schledzewski K, Olsen R, Falkowski M, Kzhyshkowska J, Carlsson F, Johansson S, Smedsrød B, Goerdt S, Johansson S, McCourt P (2005) Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding. Exp Cell Res 303: 160-73.

2004

Kzhyshkowska J, Gratchev A, Martens JH, Pervushina O, Mamidi S, Johansson S, Schledzewski K, Hansen B, He X, Tang J, Nakayama K, Goerdt S (2004) Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. J Leukoc Biol 76: 1151-61.  

McCourt PA, Hansen B, Svistuonov D, Johansson S, Longati P, Schledzewski K, Kzhyshkowska J, Goerdt S, Johansson S, Smedsrød B (2004) The liver sinusoidal endothelial cell hyaluronan receptor and its homolog, stabilin-1 - Their roles (known and unknown) in endocytosis. Comp Hepatol 3 Suppl 1: S24.

2003

Falkowski M, Schledzewski K, Hansen B, Goerdt S (2003) Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces. Histochem Cell Biol 120: 361-9.

2002

Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson  S, Goerdt S (2002) Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J 362:155-64.

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Ärztliche Leitung

Prof. Dr. med. Philipp Reiners-Koch

Geschäftsführender Oberarzt

Leiter der operativen Dermatologie
Leiter der ästhetischen Dermatologie

Facharzt für Haut- und Geschlechtskrankheiten

Prof. Dr. med. Sergij Goerdt

Direktor der Hautklinik

Facharzt für Haut- und Geschlechtskrankheiten
Allergologie
Dermatohistologie

Praktika & Abschlussarbeiten

Bei Interesse an der Mitarbeit an einem unserer Forschungsprojekte wenden Sie sich bitte an Prof. Dr. med. Sergij Goerdt  oder Dr. med. Philipp Reiners-Koch. Es besteht die Möglichkeit der Absolvierung eines Laborpraktikums, der Anfertigung einer Diplom- bzw. Masterarbeit sowie die Durchführung einer medizinischen bzw. naturwissenschaftlichen Doktorarbeit.