In our group, we focus on two lines of experiments to further investigate the basic mechanisms and functions of hepatic angiodiversity and liver function:

• Identify and functionally characterize the mechanisms and especially the transcriptional regulators and angiocrine signaling molecules that control hepatic angiodiversity and especially liver sinusoidal endothelial cell (LSEC) differentiation and function during development and in the adult organism in health and disease in models of liver regeneration, and liver fibrosis/cirrhosis, and of hepatocarcinogenesis

• Define the role of angiodiversity and of the organ-specific cellular and molecular interactions within the vascular niches in the liver and in the lymph nodes upon organotropic metastasis of malignant melanoma

   

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