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Publikationen

2018

Leibing T*, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS. (2018). Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology doi: 10.1002/hep.29613. [Epub ahead of print]

Schmid CD, Schledzewski K, Mogler C, Waldburger N, Kalna V, Marx A, Randi AM, Géraud C, Goerdt S, Koch PS. (2018) GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro. Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2018.01.185. [Epub ahead of print]

2017

Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S (2017) Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. The Journal of Clinical Investigation 127: 1099-1114.

Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantzi H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS. (2017) GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene 627: 491-499.

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C* (2017) Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 29: 415-9.

Baum C, Weiss C, Gebhardt C, Utikal J, Marx A, Koenen W, Géraud C (2017) Sentinel node metastasis mitotic rate (SN-MMR) as a prognostic indicator of rapidly progressing disease in patients with sentinel node-positive melanomas. International Journal of Cancer 140: 1907-1917.

2016

Nicolay JP, Felcht M, Schledzewski K, Goerdt S, Géraud C (2016) Sézary syndrome: old enigmas, new targets. J Dtsch Dermatol Ges: 14(3):256-6.

Biswas S, Adrian M, Weber J, Evdokimov K, , Winkler M, Géraud C (2016) Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase. Biochem Biophys Res Commun: 477(4): 661-666.

Evdokimov K, Biswas S, Schledzewski K, Winkler M, Gorzelanny C, Schneider SW, Goerdt S, Géraud C (2016) Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing. Biochem Biophys Res Commun: 475(4):342-9.

2015

Biswas S, Adrian M, Evdokimov K, Schledzewski K, Weber J, Winkler M, Goerdt S, Géraud C (2015) Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages. Biochem Biophys Res Commun: 464(4):1078-83

2014

Runge A, Hu J, Wieland M, Bergeest JP, Mogler C, Neumann A, Géraud C, Arnold B, Rohr K, Komljenovic D, Schirmacher P, Goerdt S, Augustin HG (2014) An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice. Cancer Research 74: 4157-4169

Géraud C, Koch PS, Damm F, Schledzewski K, Goerdt S (2014) The metastatic cycle: metastatic niches and cancer cell dissemination. JDDG 12: 1012-9

Géraud C, Koch PS, Goerdt S (2014) Vascular niches: endothelial cells as tissue- and site-specific multifunctional team players in health and disease. JDDG 12: 685-9

2013

Géraud C, Mogler C, Runge A, Evdokimov K, Lu S, Schledzewski K, Arnold B, Hammerling G, Koch PS, Breuhahn K, Longerich T, Marx A, Weiss C, Damm F, Schmieder A, Schirmacher P, Augustin HG, Goerdt S (2013) Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival. Liver International 33: 1428-1440

Evdokimov K, Biswas S, Adrian M, Weber J, Schledzewski K, Winkler M, Goerdt S, Géraud C (2013) Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization. Biochemical and Biophysical Research Communications 434: 22-27

2012

Géraud C, Evdokimov K, Straub BK, Peitsch WK, Demory A, Dorflinger Y, Schledzewski K, Schmieder A, Schemmer P, Augustin HG, Schirmacher P, Goerdt S (2012) Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. PloS One 7: e34206

2011

Schledzewski K, Géraud C, Arnold B, Wang S, Grone HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, Schonhaber H, Gratchev A, Dietz L, Thierse HJ, Kzhyshkowska J, Goerdt S (2011) Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. The Journal of Clinical Investigation 121: 703-714

2010

Géraud C, Schledzewski K, Demory A, Klein D, Kaus M, Peyre F, Sticht C, Evdokimov K, Lu S, Schmieder A, Goerdt S (2010) Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Hepatology 52: 313-326

Biolac-Sage P, Lepreux S, Schledzewski K, Cubel G, Géraud C, Goerdt S, Balabaud C (2010) Identification of liver sinusoidal endothelial cells in the human liver. Liver international 30: 773-776

2009

Klein D, Demory A, Peyre F, Kroll J, Géraud C, Ohnesorge N, Schledzewski K, Arnold B, Goerdt S (2009) Wnt2 acts as an angiogenic growth factor for non-sinusoidal endothelial cells and inhibits expression of stanniocalcin-1. Angiogenesis. 12: 251-265  

Zhang J, Gratchev A, Riabov V, Mamidi S, Schmuttermaier C, Krusell L, Kremmer E, Workman G, Sage EH, Jalkanen S, Goerdt S, Kzhyshkowska J (2009) A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1.

2008

Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J,  Schledzewski K, Arnold B, Goerdt S (2008) Wnt2 acts as a cell type-specific, autocrine  growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology 47: 1018-31.

2006

Kzhyshkowska J, Mamidi S, Gratchev A, Kremmer E, Schmuttermaier C, Krusell L, Haus G, Utikal J, Schledzewski K, Scholtze J, Goerdt S (2006) Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood 107: 3221-8

Schledzewski K, Falkowski M, Moldenhauer G, Metharom P, Kzhyshkowska J, Ganss  R, Demory A, Falkowska-Hansen B, Kurzen H, Ugurel S, Geginat G, Arnold B, Goerdt  S (2006) Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis. J Pathol 209: 67-77.  

Martens JH, Kzhyshkowska J, Falkowski-Hansen M, Schledzewski K, Gratchev A, Mansmann U, Schmuttermaier C, Dippel E, Koenen W, Riedel F, Sankala M, Tryggvason K, Kobzik L, Moldenhauer G, Arnold B, Goerdt S (2006) Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in  human lymph node sinuses, the primary sites of regional metastasis. J Pathol 208: 574-89.

2005

Hansen B, Longati P, Elvevold K, Nedredal GI, Schledzewski K, Olsen R, Falkowski M, Kzhyshkowska J, Carlsson F, Johansson S, Smedsrød B, Goerdt S, Johansson S, McCourt P (2005) Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding. Exp Cell Res 303: 160-73.

2004

Kzhyshkowska J, Gratchev A, Martens JH, Pervushina O, Mamidi S, Johansson S, Schledzewski K, Hansen B, He X, Tang J, Nakayama K, Goerdt S (2004) Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. J Leukoc Biol 76: 1151-61.  

McCourt PA, Hansen B, Svistuonov D, Johansson S, Longati P, Schledzewski K, Kzhyshkowska J, Goerdt S, Johansson S, Smedsrød B (2004) The liver sinusoidal endothelial cell hyaluronan receptor and its homolog, stabilin-1 - Their roles (known and unknown) in endocytosis. Comp Hepatol 3 Suppl 1: S24.

2003

Falkowski M, Schledzewski K, Hansen B, Goerdt S (2003) Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces. Histochem Cell Biol 120: 361-9.

2002

Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson  S, Goerdt S (2002) Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J 362:155-64.

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Ärztliche Leitung

Prof. Dr. med. Cyrill Géraud

Leitender Oberarzt

Leiter der Sektion Klinische- und Molekulare Dermatologie

Leiter der stationären Dermatologie

Leiter der Dermatohistologie

Facharzt für Haut- und
Geschlechtskrankheiten
Allergologie
Dermatohistologie

Praktika & Abschlussarbeiten

Bei Interesse an der Mitarbeit an einem unserer Forschungsprojekte wenden Sie sich bitte an Prof. Dr. med. Cyrill Géraud. Es besteht die Möglichkeit der Absolvierung eines Laborpraktikums, der Anfertigung einer Diplom- bzw. Masterarbeit sowie die Durchführung einer medizinischen bzw. naturwissenschaftlichen Doktorarbeit.