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Principle Investigator

Prof. Dr. med. Daniel Nowak
Head of Research Laboratory
Head of Molecular Tumor Board
Endowed Professor of the German José-Carreras-Foundation
Phone +49 621/383-71304
Fax +49 621/383-71329
daniel.nowak@ medma.uni-heidelberg.de



Preclinical 3D models of MDS and AML

Dr. sc. hum. Eva Altrock
Contact
Phone +49 621/383-71314
eva.altrock@ medma.uni-heidelberg.de
Fields of expertise
- Improvement of MDS modelling
- 3D Ossicle model as an alternative method
- 3D in vitro cell culture of MDS MSCs and HSPCs
- (PhD student: cand. med. Ann-Christin Belzer)

Preclinical testing of novel therapeutic substances

M. sc. Nanni Schmitt
Contact
Phone +49 621/383-71310
nanni.schmitt@ medma.uni-heidelberg.de
Fields of expertise
- Generation of MDS models to be used as pre-clinical platforms, and their further optimization
- Pre-clinical assessment of NK cell based therapies for treatment of AML and high-risk MDS
- (PhD student: Alexandra Beck)

Investigations of the pathomechanism of myeloid neoplasms

Dr. sc. hum. Vladimir Riabov

Dr. med. Qingyu Xu
Contact
Phone +49 621/383-71310
vladimir.ryabov@ medma.uni-heidelberg.de
Fields of expertise
- Role of MSC/HSC crosstalk in the pathogenesis of myeloid neoplasms (MDS and MPN), molecular studies (Vladimir Riabov and Qingyu Xu)
- Generation of preclinical models to therapeutically target AML/immune cell crosstalk (Vladimir Riabov)
- R-loops mediated replication stress as a novel therapeutic target in MDS with splicing factor mutations (Vladimir Riabov and MD student: Marie Demmerle)
- Investigation of the role of BM microenvironment in MDS (Vladimir Riabov and Qingyu Xu)
Contact
Phone +49 621/383-71310
qingyu.xu@ medma.uni-heidelberg.de
Fields of expertise
- Role of MSC/HSC crosstalk in the pathogenesis of myeloid neoplasms (MDS and MPN), molecular studies (Vladimir Riabov and Qingyu Xu)
- Generation of preclinical models to therapeutically target AML/immune cell crosstalk (Vladimir Riabov)
- R-loops mediated replication stress as a novel therapeutic target in MDS with splicing factor mutations (Vladimir Riabov and MD student: Marie Demmerle)
- Investigation of the role of BM microenvironment in MDS (Vladimir Riabov and Qingyu Xu)



Molecular analysis of myeloid neoplasms

Dr. med. Alexander Streuer
Contact
Phone +49 621/383-71314 or -4115
alexander.streuer@ medma.uni-heidelberg.de
Fields of expertise
- Next Generation Sequencing (RNA sequencing, whole exome sequencing, single-cell RNA sequencing)
- Pipelines for the analysis of clonal alterations of leukemic cells
- “Radiomics”- the role of spatial sampling for Contact: therapy decisions and outcome

Scientific Management/ Study Coordination

Dr. rer. med. Felicitas Rapp
Contact
Phone +49 621/383-71314
felicitas.rapp@ medma.uni-heidelberg.de
Fields of expertise
- Management of research projects
- Administration of funding
- Preparation of new clinical studies
- Coordination of ongoing studies

Technicians

Verena Nowak

Iris Palme

Julia Obländer

Melda Göl

Nadine Weimer
Contact
Phone + 49 621/383-71313
Fax +49 621/383-71329
Fields of expertise
- Research projects
- Clinical Routine: Cell culture, FACS, PCR
- Biosampling
Clinical studies
- Innovative novel therapies
- Clinical studies for patients with myelodysplastic neoplasia or leukemia
- Close interaction with scientists: “from bench to bedside”
- Contact: Prof. Daniel Nowak
Kontextspalte
José Carreras Stiftung
Gefördert durch die José Carreras Stiftung.