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Inhalt

Team

Principle Investigator

Prof. Dr. med. Daniel Nowak

Head of Research Laboratory
Head of Molecular Tumor Board
Endowed Professor of the German José-Carreras-Foundation

Phone +49 621/383-71304
Fax +49 621/383-71329
daniel.nowak@remove-this.medma.uni-heidelberg.de

Preclinical 3D models of MDS and AML

Dr. sc. hum. Eva Altrock

Contact

Fields of expertise

  • Improvement of MDS modelling
  • 3D Ossicle model as an alternative method
  • 3D in vitro cell culture of MDS MSCs and HSPCs
  • (PhD student: cand. med. Ann-Christin Belzer)

Preclinical testing of novel therapeutic substances

M. sc. Nanni Schmitt

Contact

Fields of expertise

  • Generation of MDS models to be used as pre-clinical platforms, and their further optimization
  • Pre-clinical assessment of NK cell based therapies for treatment of AML and high-risk MDS
  • (PhD student: Alexandra Beck)

Investigations of the pathomechanism of myeloid neoplasms

Dr. sc. hum. Vladimir Riabov

Dr. med. Qingyu Xu

Contact

Fields of expertise

  • Role of MSC/HSC crosstalk in the pathogenesis of myeloid neoplasms (MDS and MPN), molecular studies (Vladimir Riabov and Qingyu Xu) 
  • Generation of preclinical models to therapeutically target AML/immune cell crosstalk (Vladimir Riabov)
  • R-loops mediated replication stress as a novel therapeutic target in MDS with splicing factor mutations (Vladimir Riabov and MD student: Marie Demmerle)
  • Investigation of the role of BM microenvironment in MDS (Vladimir Riabov and Qingyu Xu)

Contact

Fields of expertise

  • Role of MSC/HSC crosstalk in the pathogenesis of myeloid neoplasms (MDS and MPN), molecular studies (Vladimir Riabov and Qingyu Xu) 
  • Generation of preclinical models to therapeutically target AML/immune cell crosstalk (Vladimir Riabov)
  • R-loops mediated replication stress as a novel therapeutic target in MDS with splicing factor mutations (Vladimir Riabov and MD student: Marie Demmerle)
  • Investigation of the role of BM microenvironment in MDS (Vladimir Riabov and Qingyu Xu)

Molecular analysis of myeloid neoplasms

Dr. med. Alexander Streuer

Contact

Fields of expertise

  • Next Generation Sequencing (RNA sequencing, whole exome sequencing, single-cell RNA sequencing)
  • Pipelines for the analysis of clonal alterations of leukemic cells
  • “Radiomics”- the role of spatial sampling for Contact: therapy decisions and outcome

Scientific Management/ Study Coordination

Dr. rer. med. Felicitas Rapp

Contact

Fields of expertise

  • Management of research projects
  • Administration of funding
  • Preparation of new clinical studies
  • Coordination of ongoing studies

Technicians

Verena Nowak

Iris Palme

Julia Obländer

Melda Göl

Nadine Weimer

Contact

Phone + 49 621/383-71313
Fax +49 621/383-71329

Fields of expertise

  • Research projects
  • Clinical Routine: Cell culture, FACS, PCR
  • Biosampling

Clinical studies

  • Innovative novel therapies
  • Clinical studies for patients with myelodysplastic neoplasia or leukemia
  • Close interaction with scientists: “from bench to bedside”
  • Contact: Prof. Daniel Nowak